Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Changes in T-cell phenotype and cytokines profile in maternal blood, cord blood and colostrum of diabetic mothers

Full text
Author(s):
Gomes Fagundes, Danny Laura [1] ; Franca, Eduardo Luzia [2] ; da Silva Fernandes, Rubian Trindade [2] ; Pernet Hara, Cristiane de Castro [2] ; Morceli, Glilciane [1] ; Honorio-Franca, Adenilda Cristina [2] ; Paranhos Calderon, Iracema de Mattos [1]
Total Authors: 7
Affiliation:
[1] Sao Paulo State Univ UNESP, Botucatu Med Sch, Grad Program Gynecol Obstet & Mastol, Sao Paulo - Brazil
[2] Univ Fed Mato Grosso, Inst Biol & Hlth Sci, Barra Do Garcas, Mato Grosso - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Journal of Maternal-Fetal & Neonatal Medicine; v. 29, n. 6, p. 998-1004, MAR 18 2016.
Web of Science Citations: 8
Abstract

Objective: The present study evaluated the cells and cytokine of maternal blood, cord blood and colostrum of diabetic mothers.Methods: The women evaluated were divided according to their body mass index (BMI) and glycemic status into non-diabetic (ND - N=15), mild gestational hyperglycemic (MGH - N=15), diabetes mellitus gestational (DMG - N=13) and type-2 diabetes mellitus (DM2 - N=15) groups. The subsets of cells and cytokine profile were determined by flow cytometry.Results: Maternal blood from MGH group had increase percentage of CD3(+)T cells, and DM-2 group had decrease percentage of CD4(+) T cells. The cord blood from hyperglycemic groups showed lower percentage of CD3(+) T cells expressing CD45RO(+) and higher of CD4(+) T cells and CD4(+) T cells expressing CD45RA(+). In the colostrum, the CD4(+) T cells and CD4(+) T cells expressed CD45RA(+) increase in hyperglycemic groups. The DM2 group exhibited higher IL17 levels in maternal blood. IFN- was lower in cord blood from MGH and DMG groups with overweight/obese. Irrespective of the glycemic status, IL6 was higher in colostrum.Conclusion: The results obtained suggest that maternal hyperglycemia modifies the phenotypes of T cells and cytokines profile in maternal, cord blood and colostrum. (AU)

FAPESP's process: 12/24212-4 - Immunomodulatory markers in maternal and fetal blood and placental tissue from women with diabetes or mild gestational hyperglycemia
Grantee:Cristiane de Castro Pernet Hara
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 12/18033-0 - Immunomodulatory markers in maternal and fetal blood and placental tissue from women with diabetes or mild gestational hyperglycemia
Grantee:Glilciane Morceli
Support Opportunities: Scholarships in Brazil - Post-Doctoral