Immunohistochemical Expression of the Pluripotency Factor OCT4 in Canine Mast Cell Tumours

Autor(es)

Vargas, T. H. M. ^[1] ; Pulz, L. H. ^{[2, 1]} ; Barra, C. N. ^{[2, 1]} ; Kleeb, S. R. ^[3] ; Xavier, J. G. ^{[4, 3]} ; Catao-Dias, J. L. ^[2] ; Fukumasu, H. ^[1] ; Nishiya, A. T. ^[5] ; Strefezzi, R. F. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Zootecnia & Engn Alimentos, Lab Oncol Comparada & Translac, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Fac Med Vet & Zootecnia, Sao Paulo - Brazil

^[3] Univ Metodista Sao Paulo, Sao Bernardo Do Campo - Brazil

^[4] Univ Estadual Paulista, Sao Paulo - Brazil

^[5] Univ Anhembi Morumbi, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Comparative Pathology; v. 153, n. 4, p. 251-255, NOV 2015.
• Citações Web of Science: 3

Resumo

Cancer stem cells (CSCs) are related to malignancy and resistance to chemotherapy in several tumours. OCT4 is a `pluripotency factor' that is expressed by these cells. The aim of the present study was to investigate OCT4 expression in canine cutaneous mast cell tumours (MCTs) by means of immunohistochemistry. Twenty-eight cases were evaluated and showed variable immunolabelling patterns. The dogs were treated by surgery alone and followed up for a minimum of 180 days. No significant difference was found between histopathological grades and similar results were obtained for mortality due to the disease and post-surgical survival. These preliminary results suggest that OCT4 expression is not a precise prognostic indicator for canine MCT. (C) 2015 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 10/05094-5 - Avaliação imuno-histoquímica das expressões de VEGF, VEGFR e metaloproteinase 9 como potenciais indicadores prognósticos para mastocitomas cutâneos caninos
• Beneficiário: Ricardo de Francisco Strefezzi
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/13252-8 - Caracterização de genes relacionados à apoptose em mastocitomas cutâneos caninos e seu valor como indicador prognóstico
• Beneficiário: Ricardo de Francisco Strefezzi
• Modalidade de apoio: Auxílio à Pesquisa - Regular