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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Immunohistochemical Expression of the Pluripotency Factor OCT4 in Canine Mast Cell Tumours

Full text
Author(s):
Vargas, T. H. M. [1] ; Pulz, L. H. [2, 1] ; Barra, C. N. [2, 1] ; Kleeb, S. R. [3] ; Xavier, J. G. [4, 3] ; Catao-Dias, J. L. [2] ; Fukumasu, H. [1] ; Nishiya, A. T. [5] ; Strefezzi, R. F. [1]
Total Authors: 9
Affiliation:
[1] Univ Sao Paulo, Fac Zootecnia & Engn Alimentos, Lab Oncol Comparada & Translac, Sao Paulo - Brazil
[2] Univ Sao Paulo, Fac Med Vet & Zootecnia, Sao Paulo - Brazil
[3] Univ Metodista Sao Paulo, Sao Bernardo Do Campo - Brazil
[4] Univ Estadual Paulista, Sao Paulo - Brazil
[5] Univ Anhembi Morumbi, Sao Paulo - Brazil
Total Affiliations: 5
Document type: Journal article
Source: Journal of Comparative Pathology; v. 153, n. 4, p. 251-255, NOV 2015.
Web of Science Citations: 3
Abstract

Cancer stem cells (CSCs) are related to malignancy and resistance to chemotherapy in several tumours. OCT4 is a `pluripotency factor' that is expressed by these cells. The aim of the present study was to investigate OCT4 expression in canine cutaneous mast cell tumours (MCTs) by means of immunohistochemistry. Twenty-eight cases were evaluated and showed variable immunolabelling patterns. The dogs were treated by surgery alone and followed up for a minimum of 180 days. No significant difference was found between histopathological grades and similar results were obtained for mortality due to the disease and post-surgical survival. These preliminary results suggest that OCT4 expression is not a precise prognostic indicator for canine MCT. (C) 2015 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 10/05094-5 - Evaluation of VEGF, VEGFR and matrix metalloproteinase-9 immunohistochemical expressions as potential prognostic indicators for canine cutaneous mast cell tumors
Grantee:Ricardo de Francisco Strefezzi
Support Opportunities: Regular Research Grants
FAPESP's process: 13/13252-8 - Characterization of apoptosis related genes in canine cutaneous mast cell tumors and its value as prognostic indicators
Grantee:Ricardo de Francisco Strefezzi
Support Opportunities: Regular Research Grants