Decreased production of proinflammatory cytokines by monocytes from individuals presenting Candida-associated denture stomatitis

Autor(es)

Pinke, Karen Henriette ^[1] ; Freitas, Patricia ^[1] ; Viera, Narciso Almeida ^[2] ; Honorio, Heitor Marques ^[3] ; Porto, Vinicius Carvalho ^[4] ; Lara, Vanessa Soares ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Bauru Sch Dent, Dept Stomatol, BR-17012901 Bauru, SP - Brazil

^[2] Univ Sao Paulo, Hosp Rehabil Craniofacial Anomalies, Clin Anal Lab, BR-17012901 Bauru, SP - Brazil

^[3] Univ Sao Paulo, Bauru Sch Dent, Dept Pediat Dent, BR-17012901 Bauru, SP - Brazil

^[4] Univ Sao Paulo, Bauru Sch Dent, Dept Prosthodont, BR-17012901 Bauru, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: CYTOKINE; v. 77, p. 145-151, JAN 2016.
• Citações Web of Science: 7

Resumo

Candida-associated denture stomatitis (DS) is the most frequent lesion among denture wearers, especially the elderly. DS is strongly associated with Candida albicans, as well as local and systemic factors, such as impaired immune response. Monocytes are important in the protective immune response against the fungus by the production of cytokines that recruit and activate leukocytes. There are functional changes in these cells with age, and individual alterations involving monocyte response may predispose the host to developing infections by Candida spp. In this study, our aim was to evaluate the production of TNF-alpha, IL-6, CXCL8, IL-1 beta, MCP-1 and IL-10 by monocytes from elderly denture wearers with/without DS and elderly or young non-denture wearers. We detected that monocytes from elderly denture wearers with Candida-related denture stomatitis produced lower levels of CXCL-8, IL-6 and MCP-I. This imbalance in cytokine levels was observed in spontaneous or LPS-stimulated production. Therefore, our data suggested that inherent aspects of the host, such as changes in cytokine production by monocytes, might be associated with the development and the persistence of DS irrespective of aging. (C) 2015 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 08/03539-0 - Estomatite por dentadura na população senescente: avaliação da ativação e da produção de citocinas pró e antiinflamatórias pelos monócitos
• Beneficiário: Vanessa Soares Lara
• Modalidade de apoio: Auxílio à Pesquisa - Regular