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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Decreased production of proinflammatory cytokines by monocytes from individuals presenting Candida-associated denture stomatitis

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Author(s):
Pinke, Karen Henriette [1] ; Freitas, Patricia [1] ; Viera, Narciso Almeida [2] ; Honorio, Heitor Marques [3] ; Porto, Vinicius Carvalho [4] ; Lara, Vanessa Soares [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Bauru Sch Dent, Dept Stomatol, BR-17012901 Bauru, SP - Brazil
[2] Univ Sao Paulo, Hosp Rehabil Craniofacial Anomalies, Clin Anal Lab, BR-17012901 Bauru, SP - Brazil
[3] Univ Sao Paulo, Bauru Sch Dent, Dept Pediat Dent, BR-17012901 Bauru, SP - Brazil
[4] Univ Sao Paulo, Bauru Sch Dent, Dept Prosthodont, BR-17012901 Bauru, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: CYTOKINE; v. 77, p. 145-151, JAN 2016.
Web of Science Citations: 7
Abstract

Candida-associated denture stomatitis (DS) is the most frequent lesion among denture wearers, especially the elderly. DS is strongly associated with Candida albicans, as well as local and systemic factors, such as impaired immune response. Monocytes are important in the protective immune response against the fungus by the production of cytokines that recruit and activate leukocytes. There are functional changes in these cells with age, and individual alterations involving monocyte response may predispose the host to developing infections by Candida spp. In this study, our aim was to evaluate the production of TNF-alpha, IL-6, CXCL8, IL-1 beta, MCP-1 and IL-10 by monocytes from elderly denture wearers with/without DS and elderly or young non-denture wearers. We detected that monocytes from elderly denture wearers with Candida-related denture stomatitis produced lower levels of CXCL-8, IL-6 and MCP-I. This imbalance in cytokine levels was observed in spontaneous or LPS-stimulated production. Therefore, our data suggested that inherent aspects of the host, such as changes in cytokine production by monocytes, might be associated with the development and the persistence of DS irrespective of aging. (C) 2015 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 08/03539-0 - Denture stomatitis in the senescent population: evaluation of activation and production of pro- and anti-inflammatory cytokines by monocytes
Grantee:Vanessa Soares Lara
Support Opportunities: Regular Research Grants