The interaction of eugenol with cell membrane models at the air-water interface is modulated by the lipid monolayer composition

Autor(es)

Goncalves, Giulia E. G. ^[1] ; de Souza, Fernanda S. ^[1] ; Lago, Joao Henrique G. ^[1] ; Caseli, Luciano ^[1]

Afiliação do(s) autor(es)

^[1] Fed Univ Sao Paulo UNIFESP, Inst Environm Chem & Pharmaceut Sci, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Biophysical Chemistry; v. 207, p. 7-12, DEC 2015.
• Citações Web of Science: 4

Resumo

Eugenol, a natural phenylpropanoid derivative with possible action in biological surfaces as microbicide, anesthetic and antioxidant, was incorporated in lipid monolayers of selected lipids at the air-water interface, representing cell membrane models. Interaction of eugenol with the lipids dipalmitoylphosphatidylcholine (DPPC), dioctadecyldimethylammonium bromide (DODAB), and dipalmitoylphosphatidylserine (DPPS) could be inferred by means of surface pressure-area isotherms and Polarization-Modulation Reflection-Absorption Spectroscopy. The interaction showed different effects on the different lipids. A higher monolayer expansion was observed for DPPS and DODAB, while more significant effects on the polar groups of the lipids were observed for DPPS and DPPC These results pointed to the fact that the interaction of eugenol with lipid monolayers at the air-water interface is modulated by the lipid composition, which may be important to comprehend at the molecular level the interaction of this drug with biological surfaces. (C) 2015 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 13/10213-1 - Interação de materiais bioativos em filmes ultrafinos organizados em modelos de biointerfaces para investigação de processos de reconhecimento molecular e mecanismos moleculares associados
• Beneficiário: Luciano Caseli
• Modalidade de apoio: Auxílio à Pesquisa - Regular