The interaction of eugenol with cell membrane models at the air-water interface is modulated by the lipid monolayer composition

Author(s)

Goncalves, Giulia E. G. ^[1] ; de Souza, Fernanda S. ^[1] ; Lago, Joao Henrique G. ^[1] ; Caseli, Luciano ^[1]

Affiliation

^[1] Fed Univ Sao Paulo UNIFESP, Inst Environm Chem & Pharmaceut Sci, Sao Paulo - Brazil

• Document type: Journal article
• Source: Biophysical Chemistry; v. 207, p. 7-12, DEC 2015.
• Web of Science Citations: 4

Abstract

Eugenol, a natural phenylpropanoid derivative with possible action in biological surfaces as microbicide, anesthetic and antioxidant, was incorporated in lipid monolayers of selected lipids at the air-water interface, representing cell membrane models. Interaction of eugenol with the lipids dipalmitoylphosphatidylcholine (DPPC), dioctadecyldimethylammonium bromide (DODAB), and dipalmitoylphosphatidylserine (DPPS) could be inferred by means of surface pressure-area isotherms and Polarization-Modulation Reflection-Absorption Spectroscopy. The interaction showed different effects on the different lipids. A higher monolayer expansion was observed for DPPS and DODAB, while more significant effects on the polar groups of the lipids were observed for DPPS and DPPC These results pointed to the fact that the interaction of eugenol with lipid monolayers at the air-water interface is modulated by the lipid composition, which may be important to comprehend at the molecular level the interaction of this drug with biological surfaces. (C) 2015 Elsevier B.V. All rights reserved. (AU)

• FAPESP's process: 13/10213-1 - Interaction of bioactive materials in ultrathin films organized in models for biointerfaces models for investigation of molecular recognition processes and associated molecular mechanisms
• Grantee: Luciano Caseli
• Support Opportunities: Regular Research Grants