Antihypertensive therapy increases natural immunity response in hypertensive patients

Autor(es):Mostrar menos -

Fonseca, Henrique Andrade R. ^[1] ; Fonseca, Francisco A. ^[1] ; Lins, Livia C. ^[1] ; Monteiro, Andrea M. ^[2] ; Bianco, Henrique T. ^[1] ; Brandao, Sergio A. ^[1] ; Povoa, Rui M. ^[1] ; Juliano, Luiz ^[3] ; Figueiredo-Neto, Antonio M. ^[4] ; Boschcov, Paulo ^[3] ; Gidlund, Magnus ^[2] ; Izar, Maria C. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Div Cardiol, Dept Med, BR-04040001 Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Dept Immunol, Inst Biomed Sci 4, Sao Paulo, SP - Brazil

^[3] Univ Fed Sao Paulo, Dept Biophys, BR-04040001 Sao Paulo, SP - Brazil

^[4] Univ Sao Paulo, Inst Phys, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Life Sciences; v. 143, p. 124-130, DEC 15 2015.
• Citações Web of Science: 2

Resumo

Aims: The aim of this work was to evaluate the effects of treatment of hypertension on the autoantibodies to apolipoprotein B-derived peptides (anti-ApoB-D peptide Abs) response, inflammation markers and vascular function. Main methods: Eighty-eight patients with hypertension (stage 1 or 2) were recruited and advised to receive perindopril (4 mg), hydrochlorothiazide (25 mg), or indapamide (1.5 mg) for 12 weeks in a blinded fashion. Office and 24-h ambulatory blood pressure monitoring (24 h ABPM), flow-mediated dilatation (FMD), nitrate-induced dilatation (NID), titers of IgG and IgM anti-ApoB-D peptide Abs, hsCRP, and interleukins (IL-8 and IL-10) were evaluated at baseline and 12 weeks after therapies. Key findings: All treatments reduced office BP, and improved FMD (P < 0.05 vs. baseline). The NID was improved only in the perindopril arm (P< 0.05 vs. baseline). The 24 h-ABPM was reduced with perindopril and hydrochlorothiazide therapies (P < 0.05 vs. baseline), but not with indapamide, and this effect was followed by increase in titers of IgM Anti-ApoB-D peptide Abs (P <0.05 vs. baseline), without modifications in titers IgG Anti-ApoB-D peptide Abs and interleulcins. Multivariable regression analysis has shown that change in the titers of IgM anti-ApoB-D peptide was associated with the changes in FMD (13 0347; P< 0.05). Significance: These findings shed light to a possible modulator effect of the antihypertensive therapy on the natural immunity responses and vascular function. (C) 2015 Elsevier Inc All rights reserved. (AU)

• Processo FAPESP: 08/57685-7 - Instituto Nacional de Ciência e Tecnologia de Fluídos Complexos
• Beneficiário: Antonio Martins Figueiredo Neto
• Modalidade de apoio: Auxílio à Pesquisa - Temático