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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Antihypertensive therapy increases natural immunity response in hypertensive patients

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Author(s):
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Fonseca, Henrique Andrade R. [1] ; Fonseca, Francisco A. [1] ; Lins, Livia C. [1] ; Monteiro, Andrea M. [2] ; Bianco, Henrique T. [1] ; Brandao, Sergio A. [1] ; Povoa, Rui M. [1] ; Juliano, Luiz [3] ; Figueiredo-Neto, Antonio M. [4] ; Boschcov, Paulo [3] ; Gidlund, Magnus [2] ; Izar, Maria C. [1]
Total Authors: 12
Affiliation:
[1] Univ Fed Sao Paulo, Div Cardiol, Dept Med, BR-04040001 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Dept Immunol, Inst Biomed Sci 4, Sao Paulo, SP - Brazil
[3] Univ Fed Sao Paulo, Dept Biophys, BR-04040001 Sao Paulo, SP - Brazil
[4] Univ Sao Paulo, Inst Phys, Sao Paulo, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Life Sciences; v. 143, p. 124-130, DEC 15 2015.
Web of Science Citations: 2
Abstract

Aims: The aim of this work was to evaluate the effects of treatment of hypertension on the autoantibodies to apolipoprotein B-derived peptides (anti-ApoB-D peptide Abs) response, inflammation markers and vascular function. Main methods: Eighty-eight patients with hypertension (stage 1 or 2) were recruited and advised to receive perindopril (4 mg), hydrochlorothiazide (25 mg), or indapamide (1.5 mg) for 12 weeks in a blinded fashion. Office and 24-h ambulatory blood pressure monitoring (24 h ABPM), flow-mediated dilatation (FMD), nitrate-induced dilatation (NID), titers of IgG and IgM anti-ApoB-D peptide Abs, hsCRP, and interleukins (IL-8 and IL-10) were evaluated at baseline and 12 weeks after therapies. Key findings: All treatments reduced office BP, and improved FMD (P < 0.05 vs. baseline). The NID was improved only in the perindopril arm (P< 0.05 vs. baseline). The 24 h-ABPM was reduced with perindopril and hydrochlorothiazide therapies (P < 0.05 vs. baseline), but not with indapamide, and this effect was followed by increase in titers of IgM Anti-ApoB-D peptide Abs (P <0.05 vs. baseline), without modifications in titers IgG Anti-ApoB-D peptide Abs and interleulcins. Multivariable regression analysis has shown that change in the titers of IgM anti-ApoB-D peptide was associated with the changes in FMD (13 0347; P< 0.05). Significance: These findings shed light to a possible modulator effect of the antihypertensive therapy on the natural immunity responses and vascular function. (C) 2015 Elsevier Inc All rights reserved. (AU)

FAPESP's process: 08/57685-7 - NICT of Complex Fluids (IFCx)
Grantee:Antonio Martins Figueiredo Neto
Support Opportunities: Research Projects - Thematic Grants