| Full text | |
| Author(s): Show less - |
Fonseca, Henrique Andrade R.
[1]
;
Fonseca, Francisco A.
[1]
;
Lins, Livia C.
[1]
;
Monteiro, Andrea M.
[2]
;
Bianco, Henrique T.
[1]
;
Brandao, Sergio A.
[1]
;
Povoa, Rui M.
[1]
;
Juliano, Luiz
[3]
;
Figueiredo-Neto, Antonio M.
[4]
;
Boschcov, Paulo
[3]
;
Gidlund, Magnus
[2]
;
Izar, Maria C.
[1]
Total Authors: 12
|
| Affiliation: | [1] Univ Fed Sao Paulo, Div Cardiol, Dept Med, BR-04040001 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Dept Immunol, Inst Biomed Sci 4, Sao Paulo, SP - Brazil
[3] Univ Fed Sao Paulo, Dept Biophys, BR-04040001 Sao Paulo, SP - Brazil
[4] Univ Sao Paulo, Inst Phys, Sao Paulo, SP - Brazil
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | Life Sciences; v. 143, p. 124-130, DEC 15 2015. |
| Web of Science Citations: | 2 |
| Abstract | |
Aims: The aim of this work was to evaluate the effects of treatment of hypertension on the autoantibodies to apolipoprotein B-derived peptides (anti-ApoB-D peptide Abs) response, inflammation markers and vascular function. Main methods: Eighty-eight patients with hypertension (stage 1 or 2) were recruited and advised to receive perindopril (4 mg), hydrochlorothiazide (25 mg), or indapamide (1.5 mg) for 12 weeks in a blinded fashion. Office and 24-h ambulatory blood pressure monitoring (24 h ABPM), flow-mediated dilatation (FMD), nitrate-induced dilatation (NID), titers of IgG and IgM anti-ApoB-D peptide Abs, hsCRP, and interleukins (IL-8 and IL-10) were evaluated at baseline and 12 weeks after therapies. Key findings: All treatments reduced office BP, and improved FMD (P < 0.05 vs. baseline). The NID was improved only in the perindopril arm (P< 0.05 vs. baseline). The 24 h-ABPM was reduced with perindopril and hydrochlorothiazide therapies (P < 0.05 vs. baseline), but not with indapamide, and this effect was followed by increase in titers of IgM Anti-ApoB-D peptide Abs (P <0.05 vs. baseline), without modifications in titers IgG Anti-ApoB-D peptide Abs and interleulcins. Multivariable regression analysis has shown that change in the titers of IgM anti-ApoB-D peptide was associated with the changes in FMD (13 0347; P< 0.05). Significance: These findings shed light to a possible modulator effect of the antihypertensive therapy on the natural immunity responses and vascular function. (C) 2015 Elsevier Inc All rights reserved. (AU) | |
| FAPESP's process: | 08/57685-7 - NICT of Complex Fluids (IFCx) |
| Grantee: | Antonio Martins Figueiredo Neto |
| Support Opportunities: | Research Projects - Thematic Grants |