Comparative study of curcumin and curcumin formulated in a solid dispersion: Evaluation of their antigenotoxic effects

Autor(es)

Mendonca, Leonardo Meneghin ^{[1, 2]} ; Machado, Carla da Silva ^{[1, 3]} ; Correia Teixeira, Cristiane Cardoso ^[4] ; Pedro de Freitas, Luis Alexandre ^[4] ; Pires Bianchi, Maria Lourdes ^[1] ; Greggi Antunes, Lusania Maria ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Anal Clin Toxicol & Bromatol, Fac Ciencias Farmaceut Ribeirao Preto, BR-14040903 Ribeirao Preto, SP - Brazil

^[2] Univ Fed Juiz de Fora, Dept Farmaceut, Governador Valadares, MG - Brazil

^[3] Univ Sao Paulo, Dept Genet, Fac Med Ribeirao Preto, BR-14040903 Ribeirao Preto, SP - Brazil

^[4] Univ Sao Paulo, Dept Ciencias Farmaceut, Fac Ciencias Farmaceut Ribeirao Preto, BR-14040903 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: GENETICS AND MOLECULAR BIOLOGY; v. 38, n. 4, p. 490-498, 2015.
• Citações Web of Science: 8

Resumo

Abstract Curcumin (CMN) is the principal active component derived from the rhizome of Curcuma longa (Curcuma longa L.). It is a liposoluble polyphenolic compound that possesses great therapeutic potential. Its clinical application is, however, limited by the low concentrations detected following oral administration. One key strategy for improving the solubility and bioavailability of poorly water-soluble drugs is solid dispersion, though it is not known whether this technique might influence the pharmacological effects of CMN. Thus, in this study, we aimed to evaluate the antioxidant and antigenotoxic effects of CMN formulated in a solid dispersion (CMN SD) compared to unmodified CMN delivered to Wistar rats. Cisplatin (cDDP) was used as the damage-inducing agent in these evaluations. The comet assay results showed that CMN SD was not able to reduce the formation of cDDP-DNA crosslinks, but it decreased the formation of micronuclei induced by cDDP and attenuated cDDP-induced oxidative stress. Furthermore, at a dose of 50 mg/kg b.w. both CMN SD and unmodified CMN increased the expression of Tp53 mRNA. Our results showed that CMN SD did not alter the antigenotoxic effects observed for unmodified CMN and showed effects similar to those of unmodified CMN for all of the parameters evaluated. In conclusion, CMN SD maintained the protective effects of unmodified CMN with the advantage of being chemically water soluble, with maximization of absorption in the gastrointestinal tract. Thus, the optimization of the physical and chemical properties of CMN SD may increase the potential for the therapeutic use of curcumin. (AU)

• Processo FAPESP: 08/53947-7 - Neurotoxicidade induzida pelo quimioterápico cisplatina: possíveis efeitos citoprotetores dos antioxidantes da dieta curcumina e coenzima Q10
• Beneficiário: Lusânia Maria Greggi Antunes
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 08/10482-4 - Avaliação de uma preparação hidrossolúvel de curcumina sobre a toxicidade induzida pelo quimioterápico cisplatina: possíveis efeitos protetores in vitro e in vivo, e identificação de alterações na expressão do gene Tp53
• Beneficiário: Leonardo Meneghin Mendonça
• Modalidade de apoio: Bolsas no Brasil - Doutorado