Levels of Osteoclastogenesis-Related Factors in the Peri-Implant Crevicular Fluid and Clinical Parameters of Immediately Loaded Implants in Patients with Osteopenia: A Short-Term Report

Autor(es)

Onuma, Tatiana ^[1] ; Aquiar, Kelly ^[1] ; Duarte, Poliana Mendes ^[1] ; Feres, Magda ^[1] ; Giro, Gabriela ^[1] ; Coelho, Paulo G. ^[2] ; Cassoni, Alessandra ^[1] ; Shibli, Jamil Awad ^[1]

Afiliação do(s) autor(es)

^[1] Univ Guarulhos, Dept Periodontol & Oral Implantol, Dent Res Div, BR-07115230 Guarulhos, SP - Brazil

^[2] NYU, Coll Dent, Biomat & Biomimet Dept, New York, NY - USA

• Tipo de documento: Artigo Científico
• Fonte: INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS; v. 30, n. 6, p. 1431-1436, NOV-DEC 2015.
• Citações Web of Science: 2

Resumo

Purpose: The aim of this prospective controlled study was to evaluate the influence of osteopenia on the levels of osteoclastogenesis-related factors in the peri-implant crevicular fluid (PICF) and on the clinical parameters of immediately loaded implants. Materials and Methods: This study included 24 patients who received at least two implants in the mandible, with restorations delivered 48 hours after implant placement. Patients were divided into control (n = 11) and osteopenia (n = 13) groups. Seven days after implant placement (baseline) and 4 months after implant placement, PICF samples were obtained, and clinical parameters (Plaque Index, Gingival Index, bleeding on probing, suppuration, probing depths, clinical attachment levels) were measured. A commercially available enzyme-linked immunosorbent assay was used to analyze PICF samples for levels of soluble receptor activator of nuclear factor of kappa B ligand (sRANKL) and osteoprotegerin (OPG). At the 4-month follow-up visit, the implant-supported restorations were removed and periapical radiographs were acquired to evaluate bone loss around the implants. Results: Eighty-eight immediately loaded implants were included in this study (38 in the control group, 50 in the osteopenia group). The RANKL and OPG levels, the RANKL/OPG ratio, and the clinical parameters were similar between the groups at both time points. However, the levels of these factors in PICF differed significantly between baseline and 4 months after surgery. Conclusion: Within the limitations of this short-term study, it can be concluded that osteopenia does not influence the PICF levels of osteoclastogenesis-related factors in immediately loaded implants after 4 months of loading. (AU)

• Processo FAPESP: 08/06972-6 - Influência da Osteoporose Tipo I sobre a Osseointegração de Implantes de Ativação Imediata.
• Beneficiário: Jamil Awad Shibli
• Modalidade de apoio: Auxílio à Pesquisa - Regular