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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Levels of Osteoclastogenesis-Related Factors in the Peri-Implant Crevicular Fluid and Clinical Parameters of Immediately Loaded Implants in Patients with Osteopenia: A Short-Term Report

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Author(s):
Onuma, Tatiana [1] ; Aquiar, Kelly [1] ; Duarte, Poliana Mendes [1] ; Feres, Magda [1] ; Giro, Gabriela [1] ; Coelho, Paulo G. [2] ; Cassoni, Alessandra [1] ; Shibli, Jamil Awad [1]
Total Authors: 8
Affiliation:
[1] Univ Guarulhos, Dept Periodontol & Oral Implantol, Dent Res Div, BR-07115230 Guarulhos, SP - Brazil
[2] NYU, Coll Dent, Biomat & Biomimet Dept, New York, NY - USA
Total Affiliations: 2
Document type: Journal article
Source: INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS; v. 30, n. 6, p. 1431-1436, NOV-DEC 2015.
Web of Science Citations: 2
Abstract

Purpose: The aim of this prospective controlled study was to evaluate the influence of osteopenia on the levels of osteoclastogenesis-related factors in the peri-implant crevicular fluid (PICF) and on the clinical parameters of immediately loaded implants. Materials and Methods: This study included 24 patients who received at least two implants in the mandible, with restorations delivered 48 hours after implant placement. Patients were divided into control (n = 11) and osteopenia (n = 13) groups. Seven days after implant placement (baseline) and 4 months after implant placement, PICF samples were obtained, and clinical parameters (Plaque Index, Gingival Index, bleeding on probing, suppuration, probing depths, clinical attachment levels) were measured. A commercially available enzyme-linked immunosorbent assay was used to analyze PICF samples for levels of soluble receptor activator of nuclear factor of kappa B ligand (sRANKL) and osteoprotegerin (OPG). At the 4-month follow-up visit, the implant-supported restorations were removed and periapical radiographs were acquired to evaluate bone loss around the implants. Results: Eighty-eight immediately loaded implants were included in this study (38 in the control group, 50 in the osteopenia group). The RANKL and OPG levels, the RANKL/OPG ratio, and the clinical parameters were similar between the groups at both time points. However, the levels of these factors in PICF differed significantly between baseline and 4 months after surgery. Conclusion: Within the limitations of this short-term study, it can be concluded that osteopenia does not influence the PICF levels of osteoclastogenesis-related factors in immediately loaded implants after 4 months of loading. (AU)

FAPESP's process: 08/06972-6 - Influence of Type I Osteoporosis on osseointegration of immediate actived implants
Grantee:Jamil Awad Shibli
Support Opportunities: Regular Research Grants