Cutaneous biocompatible rutin-loaded gelatin-based nanoparticles increase the SPF of the association of UVA and UVB filters

Autor(es):Mostrar menos -

de Oliveira, Camila Areias ^[1] ; Peres, Daniela D'Almeida ^[1] ; Graziola, Fabiana ^[1] ; Bou Chacra, Nadia Araci ^[1] ; Barros de Araujo, Gabriel Lima ^[1] ; Florido, Ana Catarina ^[2] ; Mota, Joana ^[2] ; Rosado, Catarina ^[2] ; Robles Velasco, Maria Valeria ^[1] ; Rodrigues, Luis Monteiro ^[2] ; Fernandes, Ana Sofia ^[2] ; Baby, Andre Rolim ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Pharmaceut Sci, Dept Pharm, Lab Cosmetol, BR-05508900 Sao Paulo, SP - Brazil

^[2] Univ Lusofona, Res Ctr Biosci & Hlth Technol, CBIOS, Lisbon - Portugal

• Tipo de documento: Artigo Científico
• Fonte: European Journal of Pharmaceutical Sciences; v. 81, p. 1-9, JAN 1 2016.
• Citações Web of Science: 33

Resumo

The encapsulation of natural ingredients, such as rutin, can offer improvements in sun protection effectiveness. This strategy can provide enhanced flavonoid content and produces an improved bioactive compound with new physical and functional characteristics. As an alternative to common synthetic-based sunscreens, rutin-entrapped gelatin nanoparticles (GNPs) were designed and associated with ethylhexyl dimethyl PABA (EHDP), ethylhexyl methoxycinnamate (EHMC) and methoxydibenzoylmethane (BMDBM) in sunscreen formulations. The purpose of this study was to develop rutin-loaded gelatin nanoparticles and characterize their physicochemical, thermal, functional and safety properties. Rutin-loaded gelatin nanoparticles increased antioxidant activity by 74% relative to free-rutin (FR) solution. Also, this new ingredient upgraded the Sun Protection Factor (SPF) by 48%, indicating its potential as a raw material for bioactive sunscreens. The safety profile indicated that GNPs and glutaraldehyde (GTA) decreased HaCaT cell viability in a concentration/time-dependent manner. However, both blank nanoparticles (B-NC) and rutin-loaded nanoparticles (R-NC) had good performance on skin compatibility tests. These results functionally characterized rutin-loaded nanoparticles as a safe SPF enhancer in sunscreens, especially in association with UV filters. (C) 2015 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 14/05906-0 - Estabelecimento das propriedades de segurança e eficácia clínica cosmética de sistemas nanoestruturados de base tecnológica proteica associados à rutina
• Beneficiário: Camila Areias de Oliveira
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado Direto
• Processo FAPESP: 12/19972-0 - Desenvolvimento tecnológico, avaliação da segurança e eficácia clínica de sistemas micro/nanoparticulados de gelatina contendo rutina
• Beneficiário: Camila Areias de Oliveira
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 12/04435-9 - Sistemas particulados de gelatina contendo flavonóide: desenvolvimento, caracterização e aplicação em formulações antissolares
• Beneficiário: André Rolim Baby
• Modalidade de apoio: Auxílio à Pesquisa - Regular