| Texto completo | |
| Autor(es): |
Santos, Jandyson M.
[1]
;
Vendramini, Pedro H.
[1]
;
Schwab, Nicolas V.
[1]
;
Eberlin, Marcos N.
[1]
;
de Morais, Damila R.
[1]
Número total de Autores: 5
|
| Afiliação do(s) autor(es): | [1] Univ Estadual Campinas, Inst Chem, ThoMSon Mass Spectrometry Lab, UNICAMP, BR-13083970 Campinas, SP - Brazil
Número total de Afiliações: 1
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Journal of Mass Spectrometry; v. 51, n. 1, p. 53-61, JAN 2016. |
| Citações Web of Science: | 8 |
| Resumo | |
Recently, 3-nitrobenzonitrile (3-NBN) has been used to improve sensitivity of sonic-spray ionization mass spectrometry. Easy ambient sonic-spray ionization (EASI) is one of the simplest, gentlest and most used spray-based desorption/ionization ambient techniques, but limited sensitivity has been commonly taken as its major drawback. Herein we investigate the use of 3-NBN as a dopant in EASI-MS for improved sensitivity. Using a few typical EASI samples as test cases, the presence of 10ppm (mu gml(-1)) of 3-NBN in the spray solvent showed two to fourfold gains in EASI-MS sensitivity as measured both by total ion current and S/N ratios, accompanied with significant reductions in chemical noise. Sensitivity for DESI using 3-NBN as a dopant also improved and dopant DESI versus dopant EASI sensitivities were compared. The use of solvent dopants seems therefore to be a promising strategy to improve sensitivity for spray-based ambient MS techniques. Copyright (c) 2015 John Wiley \& Sons, Ltd. (AU) | |
| Processo FAPESP: | 13/19161-4 - Petroleômica por FT-MS: Novas Estratégias de Caracterização por Pré-fracionamento de Óleos Contaminados e Emulsificados |
| Beneficiário: | Jandyson Machado Santos |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |