Proteomic profile of seminal plasma in adolescents and adults with treated and untreated varicocele

Autor(es)

Camargo, Mariana ^[1] ; Intasqui, Paula ^[1] ; Bertolla, Ricardo Pimenta ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Div Urol, Human Reprod Sect, Dept Surg, R Embau 231, BR-04039060 Sao Paulo - Brazil

^[2] Sao Paulo Hosp, Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: ASIAN JOURNAL OF ANDROLOGY; v. 18, n. 2, p. 194-201, MAR-APR 2016.
• Citações Web of Science: 15

Resumo

Varicocele, the most important treatable cause of male infertility, is present in 15% of adult males, 35% of men with primary infertility, and 80% of men with secondary infertility. On the other hand, 80% of these men will not present infertility. Therefore, there is a need to differentiate a varicocele that is exerting a deleterious effect that is treatable from a ``silent{''} varicocele. Despite the growing evidence of the cellular effects of varicocele, its underlying molecular mechanisms are still eluding. Proteomics has become a promising area to determine the reproductive biology of semen as well as to improve diagnosis of male infertility. This review aims to discuss the state-of-art in seminal plasma proteomics in patients with varicocele to discuss the challenges in undertaking these studies, as well as the future outlook derived from the growing body of evidence on the seminal proteome. (AU)

• Processo FAPESP: 14/17185-6 - Análise proteômica confirmatória de biomarcadores de alterações funcionais dos espermatozóides e estresse oxidativo seminal
• Beneficiário: Ricardo Pimenta Bertolla
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/11493-0 - Análise proteômica confirmatória de um painel de biomarcadores seminais de alterações funcionais dos espermatozoides e de estresse oxidativo seminal
• Beneficiário: Paula Intasqui Lopes
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 12/15039-7 - Efeito da varicocele e de seu tratamento nas vias proteômicas e lipidômicas e no estresse oxidativo seminal em adultos.
• Beneficiário: Mariana Camargo
• Modalidade de apoio: Bolsas no Brasil - Doutorado