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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Proteomic profile of seminal plasma in adolescents and adults with treated and untreated varicocele

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Author(s):
Camargo, Mariana [1] ; Intasqui, Paula [1] ; Bertolla, Ricardo Pimenta [1, 2]
Total Authors: 3
Affiliation:
[1] Univ Fed Sao Paulo, Div Urol, Human Reprod Sect, Dept Surg, R Embau 231, BR-04039060 Sao Paulo - Brazil
[2] Sao Paulo Hosp, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Review article
Source: ASIAN JOURNAL OF ANDROLOGY; v. 18, n. 2, p. 194-201, MAR-APR 2016.
Web of Science Citations: 15
Abstract

Varicocele, the most important treatable cause of male infertility, is present in 15% of adult males, 35% of men with primary infertility, and 80% of men with secondary infertility. On the other hand, 80% of these men will not present infertility. Therefore, there is a need to differentiate a varicocele that is exerting a deleterious effect that is treatable from a ``silent{''} varicocele. Despite the growing evidence of the cellular effects of varicocele, its underlying molecular mechanisms are still eluding. Proteomics has become a promising area to determine the reproductive biology of semen as well as to improve diagnosis of male infertility. This review aims to discuss the state-of-art in seminal plasma proteomics in patients with varicocele to discuss the challenges in undertaking these studies, as well as the future outlook derived from the growing body of evidence on the seminal proteome. (AU)

FAPESP's process: 14/17185-6 - Confirmatory proteomic analysis of biomarkers of sperm functional alteration and seminal oxidative stress
Grantee:Ricardo Pimenta Bertolla
Support Opportunities: Regular Research Grants
FAPESP's process: 14/11493-0 - Confirmatory proteomic analysis of a panel of seminal biomarkers of sperm functional abnormalities and semen oxidative stress
Grantee:Paula Intasqui Lopes
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 12/15039-7 - Varicocele effect and its treatment in proteomic and lipidomic pathways and in seminal oxidative stress in adults.
Grantee:Mariana Camargo
Support Opportunities: Scholarships in Brazil - Doctorate