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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

The influence of hubs in the structure of a neuronal network during an epileptic seizure

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Autor(es):
Rodrigues, Abner Cardoso [1, 2] ; Cerdeira, Hilda A. [3] ; Machado, Birajara Soares [1]
Número total de Autores: 3
Afiliação do(s) autor(es):
[1] Hosp Israelita Albert Einstein, Sao Paulo - Brazil
[2] Univ Sao Paulo, Bioinformat Interunits Grad Program, Sao Paulo - Brazil
[3] Univ Estadual Paulista, Inst Fis Teor, Rua Pamplona 145, BR-01405 Sao Paulo - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: European Physical Journal-Special Topics; v. 225, n. 1, p. 75-82, FEB 2016.
Citações Web of Science: 3
Resumo

In this work, we propose changes in the structure of a neuronal network with the intention to provoke strong synchronization to simulate episodes of epileptic seizure. Starting with a network of Izhikevich neurons we slowly increase the number of connections in selected nodes in a controlled way, to produce (or not) hubs. We study how these structures alter the synchronization on the spike firings interval, on individual neurons as well as on mean values, as a function of the concentration of connections for random and non-random (hubs) distribution. We also analyze how the post-ictal signal varies for the different distributions. We conclude that a network with hubs is more appropriate to represent an epileptic state. (AU)

Processo FAPESP: 11/11973-4 - ICTP Instituto Sul-Americano para Pesquisa Fundamental: um centro regional para física teórica
Beneficiário:Nathan Jacob Berkovits
Linha de fomento: Auxílio à Pesquisa - Temático