Chlorophyllin-M: A new substance for photodynamic therapy in the retina and choroid

Autor(es)

Araujo Salomao, Gustavo Henrique ^[1] ; Fernandes, Adjaci Uchoa ^[2] ; Baptista, Mauricio S. ^[3] ; Tardivo, Joao Paulo ^[4] ; Christofolini, Denise Maria ^[5] ; Correa, Joao Antonio ^[4]

Afiliação do(s) autor(es)

^[1] Fac Med ABC, Dept Ophthalmol, Sao Paulo - Brazil

^[2] Univ Camilo Castelo Branco, Inst Biomed Engn, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Dept Biochem, Sao Paulo - Brazil

^[4] Fac Med ABC, Dept Vasc Surg, Sao Paulo - Brazil

^[5] Fac Med ABC, Dept Morphol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Lasers in Surgery and Medicine; v. 47, n. 5, p. 421-425, JUL 2015.
• Citações Web of Science: 3

Resumo

Background and ObjectiveChlorophyllin-M is a new chlorophyll-based derivative photosensitive compound developed by our research group with easy laboratorial synthesis and ideal properties for photodynamic therapy (PDT). It is intended for clinical treatments with simple and low cost techniques and reagents. The objective of this study is to evaluate if intravenous chlorophyllin-M is able to deliver a photosensitizer to rabbit retina and rabbit choroid and promote PDT after ocular irradiation with a 660nm LASER. MethodsThis is a pre-clinical study. Ten eyes of five pigmented Californian rabbits were included in the study. The right eyes served as the treatment group, and the left eyes served as the control group. All eyes had been ophthalmologically evaluated and were considered normal. ResultsOphthalmic exam with anterior biomicroscopy, dilated fundus examination, and fluorescein angiography after the LASER procedure revealed normal anterior segment, retinal and choroid vessels occlusion, lumen narrowing, and capillary non-perfusion in the treated areas, indicating that PDT was successful in the treatment eyes group. ConclusionThe results of this pre-clinical study encourage future studies with this new compound. Chlorophyllin-M may become a new cost-effective agent in the retinal therapeutic arsenal. Lasers Surg. Med. 47:421-425, 2015. (c) 2015 Wiley Periodicals, Inc. (AU)

• Processo FAPESP: 13/07937-8 - Redoxoma
• Beneficiário: Ohara Augusto
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 12/50680-5 - Fotossensibilização nas ciências da vida
• Beneficiário: Mauricio da Silva Baptista
• Modalidade de apoio: Auxílio à Pesquisa - Temático