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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Chlorophyllin-M: A new substance for photodynamic therapy in the retina and choroid

Texto completo
Autor(es):
Araujo Salomao, Gustavo Henrique [1] ; Fernandes, Adjaci Uchoa [2] ; Baptista, Mauricio S. [3] ; Tardivo, Joao Paulo [4] ; Christofolini, Denise Maria [5] ; Correa, Joao Antonio [4]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Fac Med ABC, Dept Ophthalmol, Sao Paulo - Brazil
[2] Univ Camilo Castelo Branco, Inst Biomed Engn, Sao Paulo - Brazil
[3] Univ Sao Paulo, Dept Biochem, Sao Paulo - Brazil
[4] Fac Med ABC, Dept Vasc Surg, Sao Paulo - Brazil
[5] Fac Med ABC, Dept Morphol, Sao Paulo - Brazil
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: Lasers in Surgery and Medicine; v. 47, n. 5, p. 421-425, JUL 2015.
Citações Web of Science: 3
Resumo

Background and ObjectiveChlorophyllin-M is a new chlorophyll-based derivative photosensitive compound developed by our research group with easy laboratorial synthesis and ideal properties for photodynamic therapy (PDT). It is intended for clinical treatments with simple and low cost techniques and reagents. The objective of this study is to evaluate if intravenous chlorophyllin-M is able to deliver a photosensitizer to rabbit retina and rabbit choroid and promote PDT after ocular irradiation with a 660nm LASER. MethodsThis is a pre-clinical study. Ten eyes of five pigmented Californian rabbits were included in the study. The right eyes served as the treatment group, and the left eyes served as the control group. All eyes had been ophthalmologically evaluated and were considered normal. ResultsOphthalmic exam with anterior biomicroscopy, dilated fundus examination, and fluorescein angiography after the LASER procedure revealed normal anterior segment, retinal and choroid vessels occlusion, lumen narrowing, and capillary non-perfusion in the treated areas, indicating that PDT was successful in the treatment eyes group. ConclusionThe results of this pre-clinical study encourage future studies with this new compound. Chlorophyllin-M may become a new cost-effective agent in the retinal therapeutic arsenal. Lasers Surg. Med. 47:421-425, 2015. (c) 2015 Wiley Periodicals, Inc. (AU)

Processo FAPESP: 13/07937-8 - Redoxoma
Beneficiário:Ohara Augusto
Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
Processo FAPESP: 12/50680-5 - Fotossensibilização nas ciências da vida
Beneficiário:Mauricio da Silva Baptista
Linha de fomento: Auxílio à Pesquisa - Temático