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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Chlorophyllin-M: A new substance for photodynamic therapy in the retina and choroid

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Author(s):
Araujo Salomao, Gustavo Henrique [1] ; Fernandes, Adjaci Uchoa [2] ; Baptista, Mauricio S. [3] ; Tardivo, Joao Paulo [4] ; Christofolini, Denise Maria [5] ; Correa, Joao Antonio [4]
Total Authors: 6
Affiliation:
[1] Fac Med ABC, Dept Ophthalmol, Sao Paulo - Brazil
[2] Univ Camilo Castelo Branco, Inst Biomed Engn, Sao Paulo - Brazil
[3] Univ Sao Paulo, Dept Biochem, Sao Paulo - Brazil
[4] Fac Med ABC, Dept Vasc Surg, Sao Paulo - Brazil
[5] Fac Med ABC, Dept Morphol, Sao Paulo - Brazil
Total Affiliations: 5
Document type: Journal article
Source: Lasers in Surgery and Medicine; v. 47, n. 5, p. 421-425, JUL 2015.
Web of Science Citations: 3
Abstract

Background and ObjectiveChlorophyllin-M is a new chlorophyll-based derivative photosensitive compound developed by our research group with easy laboratorial synthesis and ideal properties for photodynamic therapy (PDT). It is intended for clinical treatments with simple and low cost techniques and reagents. The objective of this study is to evaluate if intravenous chlorophyllin-M is able to deliver a photosensitizer to rabbit retina and rabbit choroid and promote PDT after ocular irradiation with a 660nm LASER. MethodsThis is a pre-clinical study. Ten eyes of five pigmented Californian rabbits were included in the study. The right eyes served as the treatment group, and the left eyes served as the control group. All eyes had been ophthalmologically evaluated and were considered normal. ResultsOphthalmic exam with anterior biomicroscopy, dilated fundus examination, and fluorescein angiography after the LASER procedure revealed normal anterior segment, retinal and choroid vessels occlusion, lumen narrowing, and capillary non-perfusion in the treated areas, indicating that PDT was successful in the treatment eyes group. ConclusionThe results of this pre-clinical study encourage future studies with this new compound. Chlorophyllin-M may become a new cost-effective agent in the retinal therapeutic arsenal. Lasers Surg. Med. 47:421-425, 2015. (c) 2015 Wiley Periodicals, Inc. (AU)

FAPESP's process: 13/07937-8 - Redoxome - Redox Processes in Biomedicine
Grantee:Ohara Augusto
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 12/50680-5 - Photosensitization in life sciences
Grantee:Mauricio da Silva Baptista
Support type: Research Projects - Thematic Grants