Effect of maternal exposure to Tityus bahiensis scorpion venom during lactation on the offspring of rats

Autor(es)

Martins, Adriana do Nascimento ^{[1, 2]} ; Abranao Nencioni, Ana Leonor ^[1] ; Coronado Dorce, Ana Leticia ^[1] ; Paulo, Maria Eliza F. V. ^[1] ; Frare, Eduardo Osorio ^[1] ; Coronado Dorce, Valquiria Abrao ^[1]

Afiliação do(s) autor(es)

^[1] Butantan Inst, Pharmacol Lab, Av Dr Vital Brasil 1500, BR-05503900 Sao Paulo, SP - Brazil

^[2] Butantan Inst, Postgrad Program Toxinol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: REPRODUCTIVE TOXICOLOGY; v. 59, p. 147-158, JAN 2016.
• Citações Web of Science: 2

Resumo

Scorpion stings are a public health problem in Brazil and lactating women may be affected. We aimed to study the effects of Tityus bahiensis venom in the offspring of rats treated during lactation. Mothers received a subcutaneous injection of saline (1.0 ml/kg) or venom (2.5 mg/kg) or an intraperitoneal injection of LPS (lipopolysaccharide) (100 mu g/kg) on postnatal (PN) days 2 (PN2), 10 (PN10) or 16 (PN16). The offspring were evaluated during the childhood and adulthood. Pups showed a delay in physical and reflexological development, and a decrease in motor activity. Adults displayed low anxiety. There was an increase in the number of viable neuronal cells in hippocampal areas CA1 and CA4. The levels of IFN-gamma (interferon-gamma) increased in the experimental groups. Several of the parameters analyzed showed important differences between the sexes. Thus, the scorpion venom affects the development in the offspring of mothers envenomed during the lactation. (C) 2015 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 11/04498-8 - Exposição materna de ratas Wistar ao veneno do escorpião Tityus bahiensis durante o periodo de lactação e seus efeitos na prole.
• Beneficiário: Adriana do Nascimento Martins
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 11/10222-5 - Efeitos do veneno do escorpião Tityus bahiensis no desempenho reprodutivo materno e a participação de citocinas e de fatores de crescimento nas alterações observadas na prole de mães tratadas com o veneno no período perinatal
• Beneficiário: Ana Leonor Abrahao Nencioni Soares
• Modalidade de apoio: Auxílio à Pesquisa - Regular