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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effect of maternal exposure to Tityus bahiensis scorpion venom during lactation on the offspring of rats

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Author(s):
Martins, Adriana do Nascimento [1, 2] ; Abranao Nencioni, Ana Leonor [1] ; Coronado Dorce, Ana Leticia [1] ; Paulo, Maria Eliza F. V. [1] ; Frare, Eduardo Osorio [1] ; Coronado Dorce, Valquiria Abrao [1]
Total Authors: 6
Affiliation:
[1] Butantan Inst, Pharmacol Lab, Av Dr Vital Brasil 1500, BR-05503900 Sao Paulo, SP - Brazil
[2] Butantan Inst, Postgrad Program Toxinol, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: REPRODUCTIVE TOXICOLOGY; v. 59, p. 147-158, JAN 2016.
Web of Science Citations: 2
Abstract

Scorpion stings are a public health problem in Brazil and lactating women may be affected. We aimed to study the effects of Tityus bahiensis venom in the offspring of rats treated during lactation. Mothers received a subcutaneous injection of saline (1.0 ml/kg) or venom (2.5 mg/kg) or an intraperitoneal injection of LPS (lipopolysaccharide) (100 mu g/kg) on postnatal (PN) days 2 (PN2), 10 (PN10) or 16 (PN16). The offspring were evaluated during the childhood and adulthood. Pups showed a delay in physical and reflexological development, and a decrease in motor activity. Adults displayed low anxiety. There was an increase in the number of viable neuronal cells in hippocampal areas CA1 and CA4. The levels of IFN-gamma (interferon-gamma) increased in the experimental groups. Several of the parameters analyzed showed important differences between the sexes. Thus, the scorpion venom affects the development in the offspring of mothers envenomed during the lactation. (C) 2015 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 11/04498-8 - Maternal exposure of wistar rats to the venom of the scorpion Tityus bahiensis during lactation and its effects on the offspring.
Grantee:Adriana do Nascimento Martins
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 11/10222-5 - Effects of Tityus bahiensis venom on the maternal reproductive development and the participation of cytokines and of growth factors on the changes observed in the offspring of dames treated with the venom on the perinatal period
Grantee:Ana Leonor Abrahao Nencioni Soares
Support Opportunities: Regular Research Grants