Maternal Ingestion of Ipomoea carnea: Effects on Goat-Kid Bonding and Behavior

Autor(es)

Gotardo, Andre T. ^[1] ; Pfister, James A. ^[2] ; Raspantini, Paulo C. F. ^[1] ; Gorniak, Silvana L. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Pathol, Res Ctr Vet Toxicol CEPTOX, BR-13635900 Pirassununga - Brazil

^[2] USDA ARS, Poisonous Plant Res Lab, 1150 E 1400 N, Logan, UT 84341 - USA

• Tipo de documento: Artigo Científico
• Fonte: TOXINS; v. 8, n. 3 MAR 2016.
• Citações Web of Science: 4

Resumo

Ipomoea carnea is a toxic plant found in Brazil and other tropical and subtropical countries and often causes poisoning of livestock. The plant contains the alkaloids swainsonine and calystegines, which inhibit key cellular enzymes and cause systematic cell death. This study evaluated the behavioral effects of prenatal ingestion of this plant on dams and their kids. Twenty-four pregnant goats were randomly allocated into four treatment groups and received the following doses (g/kg BW) of fresh I. carnea: 0 (control group), 1.0 (IC1), 3.0 (IC3), and 5.0 (IC5) from day 27 of gestation until parturition. Dam and kid bonding and behavior were evaluated by several tests, immediately after birth until six weeks of age. Dams from IC3 and IC5 groups spent less time paying attention to the newborn. There was a lack of maternal-infant bonding due to I. carnea intoxication. Kids from treated dams had difficulty in standing, suckling, and in recognizing their mother hours after birth. I. carnea can also compromise the kids' ability to learn and to retain spatial memory. We suggest that kids from pregnant goats given I. carnea during gestation have significant behavioral alterations and developmental delays that may compromise their survival. (AU)

• Processo FAPESP: 06/58729-2 - Estudo da toxicidade da Ipomoea carnea em caprinos durante o período perinatal. I. Avaliação dos possíveis efeitos lesivos no tecido placentário; II. Estudos de neuroteratologia
• Beneficiário: André Tadeu Gotardo
• Modalidade de apoio: Bolsas no Brasil - Mestrado