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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Epidemiological dynamics of an urban Dengue 4 outbreak in Sao Paulo, Brazil

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Autor(es):
Villabona-Arenas, Christian Julian [1] ; de Oliveira, Jessica Luana [1, 2] ; de Sousa-Capra, Carla [3] ; Balarini, Karime [4] ; Theoto Pereira da Fonseca, Celso Ricardo [4] ; de Andrade Zanotto, Paolo Marinho [1]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Dept Microbiol, Inst Biomed Sci, Lab Mol Evolut & Bioinformat, Sao Paulo - Brazil
[2] Univ Mogi das Cruzes, Dept Biomed, Sao Paulo - Brazil
[3] Dept Hlth Guaruja, Off Epidemiol Surveillance, Sao Paulo - Brazil
[4] ITAPEMA, Clin Lab Anal Ctr, Guaruja - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: PeerJ; v. 4, APR 5 2016.
Citações Web of Science: 4
Resumo

Background: Dengue studies at the urban scale are scarce and required for guiding control efforts. In Brazil, the burden of dengue is high and challenges city public health administrations with limited resources. Here we studied the dynamics of a dengue epidemic in a single city. Methods: Serum samples from dengue suspected cases were collected and tested, from December 2012 and July 2013 in Guaruja, Brazil. We use incidence series analysis to provide a detailed view of the reproduction number dynamics and a Bayesian analysis to infer the spread of the serotype using geographic and temporal data. Results: We obtained nucleotide sequences from 354 envelope genes and georeferenced 286 samples during the course of the outbreak. Serotype 4 was responsible for the epidemic. We identified at least two major lineages that overlapped in distribution. We observed high reproduction numbers and high cladogenesis prior to the escalation of clinical case notifications. Three densely populated non-adjacent neighborhoods played a pivotal role during the onset and/or course of the epidemic. Discussion: Our findings point to high dengue virus transmission with a substantial proportion of unapparent cases that led to a late recognition of an outbreak. Usually source reductions initiatives tend to be insufficient once an epidemic has been established. Nevertheless, health authorities in Guaruja prioritized vector control on specific places with clusters of georeferenced viremic patients, which appear to have diminished the epidemic impact. (AU)

Processo FAPESP: 13/10382-8 - Detecção e genotipagem do vírus da dengue
Beneficiário:Jessica Luana de Oliveira
Linha de fomento: Bolsas no Brasil - Programa Capacitação - Treinamento Técnico
Processo FAPESP: 11/17071-2 - Filogeografia do vírus da dengue nos municípios de Jundiaí e Guarujá no estado de São Paulo
Beneficiário:Christian Julián Villabona Arenas
Linha de fomento: Bolsas no Brasil - Doutorado Direto
Processo FAPESP: 10/19059-7 - Filogeografia do vírus da dengue nos municípios de Jundiaí e Guarujá no estado de São Paulo
Beneficiário:Paolo Marinho de Andrade Zanotto
Linha de fomento: Auxílio à Pesquisa - Regular