High-intensity resistance training attenuates dexamethasone-induced muscle atrophy

Autor(es)

Krug, Andre L. O. ^[1] ; Macedo, Anderson G. ^[1] ; Zago, Anderson S. ^[2] ; Rush, James W. E. ^[3] ; Santos, Carlos F. ^[4] ; Amaral, Sandra L. ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ, Univ Fed Sao Carlos, PIPGCF UFscar UNESP, Joint Grad Program Physiol Sci, Sao Paulo - Brazil

^[2] Sao Paulo State Univ, Fac Sci, Dept Phys Educ, Ave Eng Luiz Edmundo Carrijo Coube, Sao Paulo - Brazil

^[3] Univ Waterloo, Dept Kinesiol, Fac Appl Hlth Sci, Waterloo, ON N2L 3G1 - Canada

^[4] Univ Sao Paulo, Dept Biol Sci, Bauru Sch Dent, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: MUSCLE & NERVE; v. 53, n. 5, p. 779-788, MAY 2016.
• Citações Web of Science: 6

Resumo

IntroductionIn this study we investigated the effects of high-intensity resistance training (RT) on dexamethasone (DEX)-induced muscle atrophy in flexor hallucis longus (FHL), tibialis anterior (TA), and soleus (SOL) muscles. Methods: Rats underwent either high-intensity RT or were kept sedentary. In the last 10 days they received either DEX (0.5mg/kg/day, intraperitoneally) or saline. Results: DEX reduced body weight (-21%), food intake (-28%), FHL and TA muscle mass (-20% and -18%, respectively), and increased muscle-specific ring finger 1 (MuRF-1) protein level (+37% and +45.5%). RT attenuated FHL muscle atrophy through a combination of low increase in MuRF-1 protein level (-3.5%) and significant increases in mammalian target of rapamycin (mTOR) (+63%) and p70S6K (+46% and +49% for control and DEX, respectively) protein levels. Conclusion: RT attenuated DEX-induced muscle atrophy through a combination of increases in mTOR and p70S6K protein levels and a low increase in MuRF-1 protein level. Muscle Nerve53: 779-788, 2016 (AU)

• Processo FAPESP: 12/21820-3 - Papel do exercício resistido na atrofia muscular induzida por dexametasona
• Beneficiário: André Luis de Oliveira Krug
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 11/21522-0 - Papel do sistema renina-angiotensina e do sistema nervoso simpático na hipertensão induzida por dexametasona: efeitos preventivos do exercício físico
• Beneficiário: Sandra Lia do Amaral Cardoso
• Modalidade de apoio: Auxílio à Pesquisa - Regular