High-intensity resistance training attenuates dexamethasone-induced muscle atrophy

Author(s)

Krug, Andre L. O. ^[1] ; Macedo, Anderson G. ^[1] ; Zago, Anderson S. ^[2] ; Rush, James W. E. ^[3] ; Santos, Carlos F. ^[4] ; Amaral, Sandra L. ^{[1, 2]}

Affiliation

^[1] Sao Paulo State Univ, Univ Fed Sao Carlos, PIPGCF UFscar UNESP, Joint Grad Program Physiol Sci, Sao Paulo - Brazil

^[2] Sao Paulo State Univ, Fac Sci, Dept Phys Educ, Ave Eng Luiz Edmundo Carrijo Coube, Sao Paulo - Brazil

^[3] Univ Waterloo, Dept Kinesiol, Fac Appl Hlth Sci, Waterloo, ON N2L 3G1 - Canada

^[4] Univ Sao Paulo, Dept Biol Sci, Bauru Sch Dent, Sao Paulo - Brazil

• Document type: Journal article
• Source: MUSCLE & NERVE; v. 53, n. 5, p. 779-788, MAY 2016.
• Web of Science Citations: 6

Abstract

IntroductionIn this study we investigated the effects of high-intensity resistance training (RT) on dexamethasone (DEX)-induced muscle atrophy in flexor hallucis longus (FHL), tibialis anterior (TA), and soleus (SOL) muscles. Methods: Rats underwent either high-intensity RT or were kept sedentary. In the last 10 days they received either DEX (0.5mg/kg/day, intraperitoneally) or saline. Results: DEX reduced body weight (-21%), food intake (-28%), FHL and TA muscle mass (-20% and -18%, respectively), and increased muscle-specific ring finger 1 (MuRF-1) protein level (+37% and +45.5%). RT attenuated FHL muscle atrophy through a combination of low increase in MuRF-1 protein level (-3.5%) and significant increases in mammalian target of rapamycin (mTOR) (+63%) and p70S6K (+46% and +49% for control and DEX, respectively) protein levels. Conclusion: RT attenuated DEX-induced muscle atrophy through a combination of increases in mTOR and p70S6K protein levels and a low increase in MuRF-1 protein level. Muscle Nerve53: 779-788, 2016 (AU)

• FAPESP's process: 12/21820-3 - The role of resistance exercise on muscle atrophy induced by Dexamethasone
• Grantee: André Luis de Oliveira Krug
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 11/21522-0 - Role of renin-antiotensin-system and simpathetic nervous system in dexamethasone-induced hypertension: preventive effects of exercise training
• Grantee: Sandra Lia do Amaral Cardoso
• Support Opportunities: Regular Research Grants