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Effects of physical training in lipid content and insulin resistance in skeletal muscle of patients with idiopathic inflammatory myopathies: randomized controlled trial

Grant number: 16/19771-5
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): June 01, 2017
Effective date (End): May 31, 2020
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal researcher:Samuel Katsuyuki Shinjo
Grantee:Diego Sales de Oliveira
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Dermatomyositis (DM) and polymyositis (PM) are rare systemic idiopathic inflammatory myopathies associated with high morbidity and functional disability. DM/PM patients may show as clinical consequence, increased muscle atrophy/hypotrophy associated with decreased muscle oxidative capacity. In addition, our group showed for the first time that DM/PM patients have a high prevalence of metabolic syndrome. Insulin resistance (IR) is an important component of metabolic syndrome. Increase IR in skeletal muscle affects lipids oxidation in this territory, resulting in lipids accumulation. Physical training is an important tool to increase oxidative capacity and improve IR. Thus, this study aim to evaluate the effect of physical training in IR and lipid content in skeletal muscle of DM/PM patients. Due to muscle atrophy/hypotrophy and the decrease in oxidative capacity, which are characteristic of DM/PM patients, our hypothesis is that there is a decrease in fatty acid oxidation, resulting in intramuscular lipids accumulation in these patients. This accumulation can lead to IR which in turn would damage the lipid oxidation in skeletal muscle. Physical training improves oxidative capacity and increased muscle cross sectional area. Therefore, physical training could improve fatty acids oxidation and lead to insulin resistance attenuation by reducing insulin receptor substrate-1 (IRS-1) phosphorylation. (AU)

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE OLIVEIRA, DIEGO SALES; PIRES BORGES, ISABELA BRUNA; DE SOUZA, JEAN MARCOS; GUALANO, BRUNO; RODRIGUES PEREIRA, ROSA MARIA; SHINJO, SAMUEL KATSUYUKI. Exercise training attenuates insulin resistance and improves beta-cell function in patients with systemic autoimmune myopathies: a pilot study. CLINICAL RHEUMATOLOGY, v. 38, n. 12, p. 3435-3442, DEC 2019. Web of Science Citations: 0.
DE SOUZA, J. M.; DE OLIVEIRA, D. S.; PERIN, L. A.; MISSE, R. G.; DOS SANTOS, A. M.; GUALANO, B.; DE SA PINTO, A. L.; ROSCHEL, H.; LIMA, F. R.; SHINJO, S. K. Feasibility, safety and efficacy of exercise training in immune-mediated necrotising myopathies: a quasi-experimental prospective study. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, v. 37, n. 2, p. 235-241, MAR-APR 2019. Web of Science Citations: 2.
LUIS CARLOS JACINTO; BRUNO TONICELLI TARTARINI FERNANDES; DIEGO SALES DE OLIVEIRA. Use of CMAP tools® software to teaching muscle contraction: an experience with undergraduates students in physical education. Motriz: rev. educ. fis., v. 25, n. 1, p. -, 2019.
DIEGO SALES DE OLIVEIRA; MARILDA SILVA GUIMARÃES; SAMUEL KATSUYUKI SHINJO. Insulin resistance is increased in adult patients with dermatomyositis. MedicalExpress (São Paulo, online), v. 5, p. -, 2018.

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