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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Feasibility, safety and efficacy of exercise training in immune-mediated necrotising myopathies: a quasi-experimental prospective study

de Souza, J. M. [1] ; de Oliveira, D. S. [1] ; Perin, L. A. [1] ; Misse, R. G. [1] ; dos Santos, A. M. [1] ; Gualano, B. [2, 1] ; de Sa Pinto, A. L. [1] ; Roschel, H. [2, 1] ; Lima, F. R. [1] ; Shinjo, S. K. [1]
Total Authors: 10
[1] Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Div Rheumatol, Sao Paulo - Brazil
[2] Univ Sao Paulo, Appl Physiol & Nutr Res Grp, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY; v. 37, n. 2, p. 235-241, MAR-APR 2019.
Web of Science Citations: 2

Objective To evaluate the feasibility, safety and efficacy of exercise training in patients with immune-mediated necrotising myopathies (IMNM). Methods Eight consecutive sedentary patients with IMNM (5 anti-signal recognition particle and 3 anti-hydroxy-methyl-glutaryl coenzyme A reductase) were engaged in this study. Disease status was based on International Myositis Assessment and Clinical Studies Group (IMACS) core set measures. Physical performance was evaluated by cardiopulmonary exercise test, repetition maximum (RM) protocol, handgrip dynamometry, sit-to-stand (STS) and timed up-and-go (TUG) tests. All these parameters were measured at baseline and after a 12-week, twice-a-week, supervised exercise training comprising aerobic and strength exercises. Results Patients (aged 61 years on average) were very disabled at the beginning of the disease (mean duration of 17.7 months), but after being aggressively treated with a treat-to-target approach, they presented only mild symptoms that were well-controlled with oral immunosuppression and low disease status scores by the time of the exercise intervention. No disease relapsing, worsening of the IMACS set scores or adverse events were observed throughout the training period. Patients also increased aerobic capacity (e.g. time to achieve anaerobic threshold and time to achieve exhaustion), muscle strength (e.g. 1RM bench press) and function (e.g. STS test). Conclusion Supervised exercise training did not impair disease status and seemed to be feasible, safe and effective in patients with IMNM. Moreover, exercise training increased aerobic capacity, muscle strength and function, suggesting that this could be a novel potential coadjuvant therapy in IMNM. (AU)

FAPESP's process: 17/06794-0 - Evaluation of aerobic capacity, quality of life, muscle strength and function in patients with immune-mediated necrotizing myopathy
Grantee:Letícia Alves Perin
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 17/13109-1 - Impact of physical training on resistance to insulin action, lipid content, angiogenesis and fibrogenesis of skeletal muscle in patients with idiopathic inflammatory myopathies
Grantee:Samuel Katsuyuki Shinjo
Support type: Regular Research Grants
FAPESP's process: 16/19771-5 - Effects of physical training in lipid content and insulin resistance in skeletal muscle of patients with idiopathic inflammatory myopathies: randomized controlled trial
Grantee:Diego Sales de Oliveira
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 16/23574-0 - Effects of physical training in endothelial function and functional properties of large arteries in patients with idiopathic inflammatory myopathies: A randomized controlled trial
Grantee:Rafael Giovani Misse
Support type: Scholarships in Brazil - Master