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Effects of physical training in endothelial function and functional properties of large arteries in patients with idiopathic inflammatory myopathies: A randomized controlled trial

Grant number: 16/23574-0
Support type:Scholarships in Brazil - Master
Effective date (Start): October 01, 2017
Effective date (End): September 30, 2019
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal researcher:Samuel Katsuyuki Shinjo
Grantee:Rafael Giovani Misse
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Dermatomyositis (DM) and polymyositis (PM) are rare systemic autoimmune diseases characterized by progressive and predominantly proximal member muscle weakness. In addition, they may present with cutaneous (DM), cardiorespiratory and gastrointestinal tract involvement. Metabolic syndrome (MS) is a group of diseases characterized by changes in fasting glucose, central obesity, dyslipidemia and hypertension. Patients with DM/PM show a significant prevalence of MS and diabetes mellitus, and, consequently, a high risk for cardiovascular disease (CVD). These conditions are associated to atherosclerosis, endothelial dysfunction and decreased arterial distensibility (measured by flow wave velocity - FWV). In fact, according to the literature, patients with DM/PM show an impaired endothelial function and arterial stiffness. Exercise training has been an important tool for improving physical capacity, endothelial function and arterial stiffness in patients with systemic autoimmune diseases. However, to our knowledge, there are no studies evaluating the endothelial function and arterial distensibility in patients with DM/PM submitted to exercise training, which motivated us to conduct this study.It is possible, like shown in other systemic autoimmune diseases, that exercise training will improve physical capacity, endothelial function and arterial stiffness in patients with DM/PM, which in turn, contributes to a reduction in CVD risk factors. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DOS SANTOS, ALEXANDRE MOURA; MISSE, RAFAEL GIOVANI; PIRES BORGES, ISABELA BRUNA; SHINJO, SAMUEL KATSUYUKI. The aerobic capacity in patients with antisynthetase syndrome and dermatomyositis. ADVANCES IN RHEUMATOLOGY, v. 60, n. 1 DEC 31 2019. Web of Science Citations: 0.
DE SOUZA, J. M.; DE OLIVEIRA, D. S.; PERIN, L. A.; MISSE, R. G.; DOS SANTOS, A. M.; GUALANO, B.; DE SA PINTO, A. L.; ROSCHEL, H.; LIMA, F. R.; SHINJO, S. K. Feasibility, safety and efficacy of exercise training in immune-mediated necrotising myopathies: a quasi-experimental prospective study. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, v. 37, n. 2, p. 235-241, MAR-APR 2019. Web of Science Citations: 2.
PIRES BORGES, ISABELA BRUNA; SILVA, MARILDA GUIMARES; MISSE, RAFAEL GIOVANE; SHINJO, SAMUEL KATSUYUKI. Lipid-lowering agent-triggered dermatomyositis and polymyositis: a case series and literature review. RHEUMATOLOGY INTERNATIONAL, v. 38, n. 2, p. 293-301, FEB 2018. Web of Science Citations: 6.

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