Serum cytokines and its gene expression: correlation with clinical and laboratory features and metabolic alterations of dermatomyositis/polymyositis

• Grant number: 12/07101-4
• Support Opportunities: Regular Research Grants
• Duration: August 01, 2012 - July 31, 2014
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Samuel Katsuyuki Shinjo
• Grantee: Samuel Katsuyuki Shinjo
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Fernando Henrique Carlos de Souza ; Marcela Helena Gambim Fonseca ; Sofia Silveira de Castro Miranda ; Suzana Beatriz Verissimo de Mello ; Thiago Bitar Moraes Barros

Abstract

Dermatomyositis (DM) and polymyositis (PM) are idiopathic inflammatory myopathies (IIM) characterized by chronic autoimmune myopathy, systemic, associated with high morbidity and functional disability.Immunopathologically, there are T lymphocyte and macrophage infiltrations in the PM muscle fibers, resulting in lysis of these muscle fibers. On the other hand, B lymphocytes play an important role in the pathogenesis of DM, based on: presence of autoantibodies, immune complex deposition in dermoepiderme junction of skin lesions and the B lymphocytes in perivascular areas and sore muscles. In addition, deposition of immunoglobulins and complement in the perifascicular endothelium may lead to ischaemia and muscular atrophy, showing also the importance of humoral immunity.Therefore, several cytokines have been characterized and related to the timely pathogenesis of DM / PM besides the role of cellular and humoral immunity. Although, up until now, these molecules have not been analyzed simultaneously in patients with IIM.Besides being involved in chemotaxis, modulation and recruitment of inflammatory cells in affected muscle tissues, cytokines may exert angiogenic or angiostastics role by modulating the expression of angiogenic growth factors. In practical terms, such cytokines in inflammatory conditions may quickly change the volume of local blood vessels, resulting in hypoxia, and clinically, myalgia and muscle weakness. The evaluation of these cytokines in IIM, particularly in DM may be interesting to understand the pathophysiology related to inflammatory vasculopathy.Besides the key role of cytokines in the immune mechanism, inflammation and angiogenesis, cytokines also had been described role in metabolic syndrome. This syndrome is a multifactorial disease characterized by high prevalence change in fasting glucose / insulin resistance, central obesity, dyslipidemia and hypertension, which ultimately not only increases the risk of cardiovascular disease, but is also associated with a picture of systemic inflammation and nonspecific. In MII, based on few studies, there is only indirect evidence of increased prevalence of metabolic syndrome, and no study analyzing the cytokines involved in this syndrome in DM/PM.Based on these immunopathological findings, it is relevant to the characterization of serum cytokines as peripheral biomarkers, correlating data with disease activity, clinical and laboratory manifestations and metabolic abnormalities found in patients with DM/PM. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ARAUJO, P. A. O.; SILVA, M. G.; BORBA, E. F.; SHINJO, S. K.. High prevalence of metabolic syndrome in antisynthetase syndrome. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, v. 36, n. 2, p. 241-247, MAR-APR 2018. (12/07101-4)

DIEGO SALES DE OLIVEIRA; MARILDA SILVA GUIMARÃES; SAMUEL KATSUYUKI SHINJO. RESISTÊNCIA INSULÍNICA AUMENTADA EM PACIENTES COM DERMATOMIOSITE. MedicalExpress (São Paulo, online), v. 5, 2018-10-22. (16/19771-5, 12/07101-4)

PAMPLONA DA SILVA, THIAGO COSTA; SILVA, MARILDA GUIMARAES; SHINJO, SAMUEL KATSUYUKI. Relevance of serum angiogenic cytokines in adult patients with dermatomyositis. ADVANCES IN RHEUMATOLOGY, v. 58, JUL 31 2018. (12/09633-3, 12/07101-4)

MIOSSI, RENATA; CARLOS DE SOUZA, FERNANDO HENRIQUE; SHINJO, SAMUEL KATSUYUKI. Nailfold capillary changes in adult new-onset dermatomyositis: a prospective cross-sectional study. CLINICAL RHEUMATOLOGY, v. 38, n. 9, p. 2319-2326, SEP 2019. (12/07101-4)