The idiopathic inflammatory myopathies (IIM) are a heterogeneous group of chronic autoimmune disease, systemic, associated with high morbidity and functional disability. Considering the clinical and histopathological features, the MII can be classified into polymyositis (PM), dermatomyositis (DM), juvenile dermatomyositis (JDM), inclusion body myositis (IBM), myositis associated with malignancy and myositis associated with other collagen diseases. The etiologies of both DM and PM remain unknown, but it is believed to be multifactorial, involving genetic, immunological and environmental features.Unlike other systemic autoimmune diseases, there are not studies analyzing specifically the gonadal function, cervical dysplasia and sexual dysfunction in patient with DM and PM, as well as their correlation with clinical and laboratory features and drug therapy. All these aspects will be analyzed in the present project. (AU)
Articles published in Agência FAPESP Newsletter about the research grant:
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CARLOS DE SOUZA, FERNANDO HENRIQUE;
DA SILVA, CLOVIS ARTUR;
SHIGUEHARA YAMAKAMI, LUCAS YUGO;
TRINDADE VIANA, VILMA DOS SANTOS;
SHINJO, SAMUEL KATSUYUKI.
Reduced ovarian reserve in patients with adult polymyositis.
Web of Science Citations: 7.