Profile and prevalence of myositis-specific autoantibodies and myositis-associated in the Brazilian population with Dermatomyositis/Polymyositis

• Grant number: 12/03399-9
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): May 01, 2012
• Effective date (End): April 30, 2013
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Samuel Katsuyuki Shinjo
• Grantee: Marcela Gran Pina Cruellas
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The idiopathic inflammatory myopathies (IIM) are a heterogeneous group of chronic autoimmune diseases, systemic, associated with high morbidity and functional disability. Considering the clinical and histopathological features, the MII can be classified into polymyositis (PM), dermatomyositis (DM), juvenile dermatomyositis (JDM), and inclusion body myositis (IBM), myositis associated with malignancy and myositis associated with other collagen diseases. The etiology of both DM and PM remains unknown but is believed to be multifactorial involving genetic, immunological, and environmental. Thus, the presence of lymphocytic infiltrates in muscle tissue in most patients with IIM, as well as myositis-specific autoantibodies and myositis-associated circulation and deposits in the endothelial cells of blood vessels found in muscle biopsies, strongly suggest the involvement of processes in the pathogenesis of IIM immune compromising muscle function. On the other hand, the description of these autoantibodies has allowed a better characterization of the diagnosis of IIM and extrapolates their possible associations with clinical, immunogenetic, evolution, and prognosis. However, to date, no reports of evaluation of the profile and the distribution of these autoantibodies in the Brazilian population with DM / PM and its clinical association. Thus, it would be of interest to establish a comparison of the reactivity pattern of our patients with that already described in other populations.(AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FERNANDO HENRIQUE CARLOS DE SOUZA; MARCELA GRAN PINA CRUELLAS; MAURICIO LEVY-NETO; SAMUEL KATSUYUKI SHINJO. Síndrome antissintetase: anti-PL-7, anti-PL-12 e anti-EJ. REVISTA BRASILEIRA DE REUMATOLOGIA, v. 53, n. 4, p. 352-357, 2013-08-00. (11/12700-1, 12/03399-9)