Profile and prevalence of myositis-specific and myositis-associated autoantibodies in Brazilian population with dermatomyositis/polymyositis

• Grant number: 11/12700-1
• Support Opportunities: Regular Research Grants
• Start date: September 01, 2011
• End date: August 31, 2013
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Samuel Katsuyuki Shinjo
• Grantee: Samuel Katsuyuki Shinjo
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The idiopathic inflammatory myopathies (IIM) are a heterogeneous group of chronic autoimmune disease, systemic, associated with high morbidity and functional disability. Considering the clinical and histopathological features, the MII can be classified into polymyositis (PM), dermatomyositis (DM), juvenile dermatomyositis (JDM), inclusion body myositis (IBM), myositis associated with malignancy and myositis associated with other collagen diseases. The etiology of both DM and PM remains unknown, but is believed to be multifactorial involving genetic, immunological and environmental. Thus, the presence of lymphocytic infiltrates in muscle tissue in most patients with IIM, as well as myositis-specific autoantibodies and myositis-associated circulation and deposits in the endothelial cells of blood vessels found in muscle biopsies, strongly suggest the involvement of processes in the pathogenesis of IIM immune compromising muscle function. On the other hand, the description of these autoantibodies has allowed a better characterization of the diagnosis of IIM, and extrapolate their possible associations with clinical, immunogenetic, evolution, and prognosis. However, to date, no reports of evaluation of the profile and the distribution of these autoantibodies in the Brazilian population with DM / PM and its clinical association. Thus, it would be of interest to establish a comparison of the reactivity pattern of our patients with that already described in other populations. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FERNANDO HENRIQUE CARLOS DE SOUZA; MARCELA GRAN PINA CRUELLAS; MAURICIO LEVY-NETO; SAMUEL KATSUYUKI SHINJO. Síndrome antissintetase: anti-PL-7, anti-PL-12 e anti-EJ. REVISTA BRASILEIRA DE REUMATOLOGIA, v. 53, n. 4, p. 352-357, 2013-08-00. (12/03399-9, 11/12700-1)

CARDOSO DOS PASSOS CARVALHO, MARIA ISABEL; SHINJO, SAMUEL KATSUYUKI. Frequency and clinical relevance of anti-Mi-2 autoantibody in adult Brazilian patients with dermatomyositis. ADVANCES IN RHEUMATOLOGY, v. 59, JUL 2 2019. (11/12700-1)

DE SOUZA, F. H. C.; MIOSSI, R.; SHINJO, S. K.. Necrotising myopathy associated with anti-signal recognition particle (anti-SRP) antibody. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, v. 35, n. 5, p. 766-771, SEP-OCT 2017. (14/09079-1, 11/12700-1)

MARCELA GRAN PINA CRUELLAS; VILMA DOS SANTOS TRINDADE VIANA; MAURÍCIO LEVY-NETO; FERNANDO HENRIQUE CARLOS DE SOUZA; SAMUEL KATSUYUKI SHINJO. Myositis-specific and myositis-associated autoantibody profiles and their clinical associations in a large series of patients with polymyositis and dermatomyositis. Clinics, v. 68, n. 7, p. 909-914, 2013-07-00. (11/12700-1)

AGUILA, LISBETH ARANBICIA; UGOLINI LOPES, MICHELLE REMIAO; PRETTI, FLAVIA ZON; SAMPAIO-BARROS, PERCIVAL DEGRAVA; CARLOS DE SOUZA, FERNANDO HENRIQUE; BORBA, EDUARDO FERREIRA; SHINJO, SAMUEL KATSUYUKI. Clinical and laboratory features of overlap syndromes of idiopathic inflammatory myopathies associated with systemic lupus erythematosus, systemic sclerosis, or rheumatoid arthritis. CLINICAL RHEUMATOLOGY, v. 33, n. 8, p. 1093-1098, AUG 2014. (11/12700-1)