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Prevalence and reactivity of the myositis-specific autoantibodies (anti-TIF-1g, anti-NXP-2 and anti-SAE) in adult patients with dermatomyositis: a prospective cohort sutdy

Grant number: 21/04892-0
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): August 01, 2021
Effective date (End): July 31, 2022
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal researcher:Samuel Katsuyuki Shinjo
Grantee:Natássia Cristina Carboni Truzzi
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Dermatomyositis is a rare systemic autoimmune myopathy, characterized by primary involvement of the skin and striated muscle that leads to the functional disability with a high rate of morbidity and mortality. Several myositis-specific autoantibodies, including anti-Jo-1, anti-Mi-2, anti-TIF-1³, anti-NXP-2, anti-MDA-5, and anti-SAE allow to characterize it phenotypically, as well as how to establish possible associations with their clinical manifestations and prognosis. The literature related to this topic is scarce and most studies are limited to reports, or case series, or retrospective studies, with the heterogeneous cohort, consisting of patients with dermatomyositis and other systemic autoimmune myopathies, whose method used for the analysis of autoantibodies were not specific. However, such studies made it possible to show the association between autoantibodies and the origin of the analyzed population (geographic site). Our group was the first in assessing the prevalence and reactivity of anti-Mi-2, anti-Jo-1, and anti-MDA-5 in a representative sample, consisting exclusively of patients with dermatomyositis. This fact enabled a better characterization of the disease, as well as establishing potential manifestations specific to our population. The aim of the present study is to assess, by the method of immunoblotting, the prevalence/reactivity of myositis-specific autoantibodies, especially those that have not yet been studied in our country, anti-TIF-1³, anti-SAE, and anti-NXP-2, in addition to determining a correlation with the profiles of such autoantibodies, with the manifestations of dermatomyositis, and thereby, establishing a contemporary demographic, clinical and laboratory profile of these patients. For such purpose, a prospective study will be carried out, with a representative and homogeneous sample of patients with dermatomyositis. With the results obtained in this study, we seek to contribute to the more homogeneous characterization of Brazilian patients, and thus establish the profile of such autoantibodies in the disease, in this population. (AU)

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