Advanced search
Start date

Impact of physical training on resistance to insulin action, lipid content, angiogenesis and fibrogenesis of skeletal muscle in patients with idiopathic inflammatory myopathies


Idiopathic inflammatory myopathies (MII) are rare systemic autoimmune diseases associated with high morbidity and functional disability. They can be classified as dermatomyositis (DM), polymyositis (PM), immune-mediated necrotizing myopathy (IMNM), inclusion body myositis (IBM), among others. Patients have primarilt skeletal muscle involvement, accompanied by decreased muscle strength, muscle function, quality of life and aerobic capacity. In addition, they present muscle atrophy/hypotrophy, associated with increased fibrogenesis and lipogenesis, and decreased angiogenesis and oxidative capacity of lipids in muscle tissues. Moreover, our group showed for the first time in the literature that patients with MII have a high prevalence of metabolic syndrome and a peripheral increase of insulin resistance (IR). Increased IR in skeletal muscle further impairs oxidation of lipids in this territory, culminating in the accumulation of this metabolite. In this context, physical training could improve and favor oxidative capacity and angiogenesis. On the other hand, it could attenuate IR, as well as the mechanism of lipogenesis and fibrogenesis in muscle tissues. Clinically, there would be improvement of aerobic capacity, muscle strength and function, quality of life, and decrease of morbimortality. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
More itemsLess items

Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DOS SANTOS, ALEXANDRE MOURA; MISSE, RAFAEL GIOVANI; PIRES BORGES, ISABELA BRUNA; SHINJO, SAMUEL KATSUYUKI. The aerobic capacity in patients with antisynthetase syndrome and dermatomyositis. ADVANCES IN RHEUMATOLOGY, v. 60, n. 1 DEC 31 2019. Web of Science Citations: 0.
DE OLIVEIRA, DIEGO SALES; PIRES BORGES, ISABELA BRUNA; DE SOUZA, JEAN MARCOS; GUALANO, BRUNO; RODRIGUES PEREIRA, ROSA MARIA; SHINJO, SAMUEL KATSUYUKI. Exercise training attenuates insulin resistance and improves beta-cell function in patients with systemic autoimmune myopathies: a pilot study. CLINICAL RHEUMATOLOGY, v. 38, n. 12, p. 3435-3442, DEC 2019. Web of Science Citations: 0.
DE SOUZA, JEAN MARCOS; HOFF, LEONARDO SANTOS; SHINJO, SAMUEL KATSUYUKI. Intravenous human immunoglobulin and/or methylprednisolone pulse therapies as a possible treat-to-target strategy in immune-mediated necrotizing myopathies. RHEUMATOLOGY INTERNATIONAL, v. 39, n. 7, p. 1201-1212, JUL 2019. Web of Science Citations: 0.
DE SOUZA, J. M.; DE OLIVEIRA, D. S.; PERIN, L. A.; MISSE, R. G.; DOS SANTOS, A. M.; GUALANO, B.; DE SA PINTO, A. L.; ROSCHEL, H.; LIMA, F. R.; SHINJO, S. K. Feasibility, safety and efficacy of exercise training in immune-mediated necrotising myopathies: a quasi-experimental prospective study. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, v. 37, n. 2, p. 235-241, MAR-APR 2019. Web of Science Citations: 2.
DE OLIVEIRA, DIEGO SALES; MISSE, RAFAEL GIOVANI; LIMA, FERNANDA RODRIGUES; SHINJO, SAMUEL KATSUYUKI. Physical exercise among patients with systemic autoimmune myopathies. ADVANCES IN RHEUMATOLOGY, v. 58, MAY 24 2018. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: