Autor(es)

de Souza, J. M. ^[1] ; de Oliveira, D. S. ^[1] ; Perin, L. A. ^[1] ; Misse, R. G. ^[1] ; dos Santos, A. M. ^[1] ; Gualano, B. ^{[2, 1]} ; de Sa Pinto, A. L. ^[1] ; Roschel, H. ^{[2, 1]} ; Lima, F. R. ^[1] ; Shinjo, S. K. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Div Rheumatol, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Appl Physiol & Nutr Res Grp, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY; v. 37, n. 2, p. 235-241, MAR-APR 2019.
• Citações Web of Science: 2

Resumo

Objective To evaluate the feasibility, safety and efficacy of exercise training in patients with immune-mediated necrotising myopathies (IMNM). Methods Eight consecutive sedentary patients with IMNM (5 anti-signal recognition particle and 3 anti-hydroxy-methyl-glutaryl coenzyme A reductase) were engaged in this study. Disease status was based on International Myositis Assessment and Clinical Studies Group (IMACS) core set measures. Physical performance was evaluated by cardiopulmonary exercise test, repetition maximum (RM) protocol, handgrip dynamometry, sit-to-stand (STS) and timed up-and-go (TUG) tests. All these parameters were measured at baseline and after a 12-week, twice-a-week, supervised exercise training comprising aerobic and strength exercises. Results Patients (aged 61 years on average) were very disabled at the beginning of the disease (mean duration of 17.7 months), but after being aggressively treated with a treat-to-target approach, they presented only mild symptoms that were well-controlled with oral immunosuppression and low disease status scores by the time of the exercise intervention. No disease relapsing, worsening of the IMACS set scores or adverse events were observed throughout the training period. Patients also increased aerobic capacity (e.g. time to achieve anaerobic threshold and time to achieve exhaustion), muscle strength (e.g. 1RM bench press) and function (e.g. STS test). Conclusion Supervised exercise training did not impair disease status and seemed to be feasible, safe and effective in patients with IMNM. Moreover, exercise training increased aerobic capacity, muscle strength and function, suggesting that this could be a novel potential coadjuvant therapy in IMNM. (AU)

• Processo FAPESP: 17/13109-1 - Impacto do treinamento físico na resistência a ação da insulina, conteúdo lipídico, angiogênese e fibrogênese do músculo esquelético de pacientes com miopatias inflamatórias idiopáticas
• Beneficiário: Samuel Katsuyuki Shinjo
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 16/23574-0 - Efeitos do treinamento físico na função endotelial e nas propriedades funcionais de grandes artérias de pacientes com miopatias inflamatórias idiopáticas: Ensaio clínico controlado e randomizado
• Beneficiário: Rafael Giovani Misse
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 17/06794-0 - Avaliação da capacidade aeróbia, qualidade de vida, força e função muscular em pacientes com miopatia necrosante imunomediada
• Beneficiário: Letícia Alves Perin
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 16/19771-5 - Efeitos do treinamento físico no conteúdo lipídico e na resistência à ação da insulina do músculo esquelético de pacientes com miopatias inflamatórias idiopáticas: ensaio clínico controlado e randomizado
• Beneficiário: Diego Sales de Oliveira
• Modalidade de apoio: Bolsas no Brasil - Doutorado