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Effects of exercise training in patients undergoing bariatric surgery: a randomized and clinical trial

Abstract

Obesity is defined by excessive accumulation of body fat, usually measured and rated by measuring the height and weight of the individual. Thus, obesity can be defined as BMI and 30 kg / m2. In Brazil, we use the term morbid obesity to be defined extreme cases of obesity. Thus, Morbid obesity is defined as BMI and 40 kg / m2 or greater than 35 kg / m2 associated with significant morbidities (Gastrointestinal Surgery for Severe Obesity: National Institutes of Health Consensus Development Conference 1991). It is a worldwide public health problem and its prevalence is increasing significantly. From the 80s, obesity has become a global epidemic in different age groups of the population (Engeland et al., 2003), with an estimate by the World Health Organization (WHO) the existence of approximately 500 million obese with body mass index (BMI) above 30 kg / m2 (STURM, 2003). Even more alarmingly, it is estimated that the number of morbidly obese people has increased fivefold in the last 15 years (Dimick and Birkmeyer, 2014).The relationship of obesity with increased mortality is associated with the presence of various comorbidities such as hypertension (HAS), diabetes mellitus type 2 (DM2), cancer, non-alcoholic fatty liver disease and cardiovascular disease (MAGLIO et al. 2013; LAVIE et al, 2014;. NGUYEN et al, 2014;. RODRIGUEZ-GALLEGO et al, 2014;. YOUNG et al, 2014).. Importantly, studies have shown that obese individuals have reduced cardiorespiratory fitness, represented by the peak oxygen consumption (VO2peak), and that an independent predictor of mortality from all causes and from cardiovascular disease (BLAIR et al, 1995;. FERREIRA et al., 2003). However, this reduction of VO2max. and, consequently, increased chance of mortality, it does not seem to be dependent on BMI and total adiposity (KODAMA et al., 2009). Thus, the high prevalence of physical inactivity certainly seems to explain, even partially, low cardiorespiratory fitness in obese individuals, especially in morbidly obese (GALLAGHER et al., 2005).The reduction in body weight (through bariatric surgery or not) and exercise are important treatment options in the clinical management of obesity. However, there remains a discussion of the respective additive effects of exercise training in patients undergoing bariatric surgery. In addition, recent reviews highlight that further studies are needed to elucidate the effect of exercise training in patients undergoing bariatric surgery. Thus, this project will address the following issues:1) Exercise training is able to attenuate bone mass reduction in patients undergoing bariatric surgery?2) Exercise training is able to attenuate muscle atrophy in patients undergoing bariatric surgery?3) Exercise training can optimize the improvement of insulin resistance in skeletal muscle in individuals undergoing bariatric surgery for the improvement of the angiogenic process in skeletal muscle? (AU)

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VEICULO: TITULO (DATA)

Scientific publications (7)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GIL, SAULO; PECANHA, TIAGO; DANTAS, WAGNER S.; MURAI, IGOR HISASHI; ABUJABRA MEREGE-FILHO, CARLOS ALBERTO; DE SA-PINTO, ANA LUCIA; RODRIGUES PEREIRA, ROSA MARIA; DE CLEVA, ROBERTO; SANTO, MARCO AURELIO; NUNES REZENDE, DIEGO AUGUSTO; KIRWAN, JOHN P.; GUALANO, BRUNO; ROSCHEL, HAMILTON. Exercise Enhances the Effect of Bariatric Surgery in Markers of Cardiac Autonomic Function. OBESITY SURGERY, OCT 2020. Web of Science Citations: 0.
DANTAS, WAGNER S.; ROSCHEL, HAMILTON; MURAI, IGOR H.; GIL, SAULO; DAVULURI, GANGARAO; AXELROD, CHRISTOPHER L.; GHOSH, SUJOY; NEWMAN, SUSAN S.; ZHANG, HUI; SHINJO, SAMUEL K.; DAS NEVES, WILLIAN; MEREGE-FILHO, CARLOS; TEODORO, WALCY R.; CAPELOZZI, VERA L.; PEREIRA, ROSA MARIA; BENATTI, FABIANA B.; DE SA-PINTO, ANA L.; DE CLEVA, ROBERTO; SANTO, MARCO A.; KIRWAN, JOHN P.; GUALANO, BRUNO. Exercise-Induced Increases in Insulin Sensitivity After Bariatric Surgery Are Mediated By Muscle Extracellular Matrix Remodeling. Diabetes, v. 69, n. 8, p. 1675-1691, AUG 2020. Web of Science Citations: 0.
MURAI, IGOR H.; ROSCHEL, HAMILTON; DANTAS, WAGNER S.; GIL, SAULO; MEREGE-FILHO, CARLOS; DE CLEVA, ROBERTO; DE SA-PINTO, ANA L.; LIMA, FERNANDA; SANTO, MARCO A.; BENATTI, FABIANA B.; KIRWAN, JOHN P.; PEREIRA, ROSA M.; GUALANO, BRUNO. Exercise Mitigates Bone Loss in Women With Severe Obesity After Roux-en-Y Gastric Bypass: A Randomized Controlled Trial. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, v. 104, n. 10, p. 4639-4650, OCT 2019. Web of Science Citations: 0.
BASSINELLO, DIOGO; PAINELLI, VITOR DE SALLES; DOLAN, EIMEAR; LIXANDRAO, MANOEL; CAJUEIRO, MONIQUE; DE CAPITANI, MARIANA; SAUNDERS, BRYAN; SALE, CRAIG; ARTIOLI, GUILHERME G.; GUALANO, BRUNO; ROSCHEL, HAMILTON. Beta-alanine supplementation improves isometric, but not isotonic or isokinetic strength endurance in recreationally strength-trained young men. Amino Acids, v. 51, n. 1, p. 27-37, JAN 2019. Web of Science Citations: 2.
DOLAN, E.; SAUNDERS, B.; DANTAS, W. S.; MURAI, I. H.; ROSCHEL, H.; ARTIOLI, G. G.; HARRIS, R.; BICUDO, J. E. P. W.; SALE, C.; GUALANO, B. A Comparative Study of Hummingbirds and Chickens Provides Mechanistic Insight on the Histidine Containing Dipeptide Role in Skeletal Muscle Metabolism. SCIENTIFIC REPORTS, v. 8, OCT 3 2018. Web of Science Citations: 3.
FERRAZ, RODRIGO BRANCO; GUALANO, BRUNO; RODRIGUES, REYNALDO; KURIMORI, CECI OBARA; FULLER, RICARDO; LIMA, FERNANDA RODRIGUES; DE SA-PINTO, ANA LUCIA; ROSCHEL, HAMILTON. Benefits of Resistance Training with Blood Flow Restriction in Knee Osteoarthritis. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, v. 50, n. 5, p. 897-905, MAY 2018. Web of Science Citations: 16.
LIXANDRAO, MANOEL E.; UGRINOWITSCH, CARLOS; BERTON, RICARDO; VECHIN, FELIPE C.; CONCEICAO, MIGUEL S.; DAMAS, FELIPE; LIBARDI, CLEITON A.; ROSCHEL, HAMILTON. Magnitude of Muscle Strength and Mass Adaptations Between High-Load Resistance Training Versus Low-Load Resistance Training Associated with Blood-Flow Restriction: A Systematic Review and Meta-Analysis. SPORTS MEDICINE, v. 48, n. 2, p. 361-378, FEB 2018. Web of Science Citations: 39.

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