Host gene constraints and genomic context impact the expression and evolution of human microRNAs

Autor(es)

Franca, Gustavo S. ^{[1, 2]} ; Vibranovski, Maria D. ^[3] ; Galante, Pedro A. F. ^[1]

Afiliação do(s) autor(es)

^[1] Hosp Sirio Libanes, Ctr Oncol Mol, Rua Daher Cutait 69, BR-01308060 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Inst Quim, Dept Bioquim, Av Prof Lineu Prestes 748, BR-05508000 Sao Paulo - Brazil

^[3] Univ Sao Paulo, Dept Genet & Biol Evolut, Rua Matao 277, BR-05508090 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: NATURE COMMUNICATIONS; v. 7, APR 2016.
• Citações Web of Science: 15

Resumo

Increasing evidence has shown that recent miRNAs tend to emerge within coding genes. Here we conjecture that human miRNA evolution is tightly influenced by the genomic context, especially by host genes. Our findings show a preferential emergence of intragenic miRNAs within old genes. We found that miRNAs within old host genes are significantly more broadly expressed than those within young ones. Young miRNAs within old genes are more broadly expressed than their intergenic counterparts, suggesting that young miRNAs have an initial advantage by residing in old genes, and benefit from their hosts' expression control and from the exposure to diverse cellular contexts and target genes. Our results demonstrate that host genes may provide stronger expression constraints to intragenic miRNAs in the long run. We also report associated functional implications, highlighting the genomic context and host genes as driving factors for the expression and evolution of human miRNAs. (AU)

• Processo FAPESP: 11/19645-6 - Análise do perfil de expressão de microRNAs e sua associação com resposta a drogas quimioterápicas em linhagens celulares de tumor de cólon
• Beneficiário: Gustavo Starvaggi França
• Modalidade de apoio: Bolsas no Brasil - Doutorado