Frontal Lobe Degeneration in Adults with Down Syndrome and Alzheimer's Disease: A Review

Autor(es)

Fonseca, Luciana Mascarenhas ^[1] ; Yokomizo, Juliana Emy ^[1] ; Bottino, Cassio Machado ^[1] ; Fuentes, Daniel ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Med, Old Age Res Grp PROTER, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sch Med, Integrated Labs Neuropsychol LINEU, Dept Psychiat, Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: DEMENTIA AND GERIATRIC COGNITIVE DISORDERS; v. 41, n. 3-4, p. 123-136, 2016.
• Citações Web of Science: 5

Resumo

Background: There is a proven link between Down syndrome and the early development of the neuropathological features of Alzheimer's disease (AD). Changes in the personality and behavior of adults with Down syndrome might indicate the early stages of dementia or of frontotemporal lobar degeneration. The objective of this study was to investigate the executive functions and changes in behavior associated with frontal lobe degeneration in individuals with Down syndrome who develop AD. We conducted a systematic review selecting studies employing cognitive assessments. Summary: We identified few studies using objective measurements to determine whether cognitive aspects associated with the frontal lobe correlate with dementia in this population. We observed a tendency toward such correlations. (C) 2016 S. Karger AG, Basel (AU)

• Processo FAPESP: 13/11571-9 - Investigação sobre fatores de risco para declínio cognitivo e demência em adultos com Síndrome de Down e validação do CAMDEX-DS
• Beneficiário: Luciana Mascarenhas Fonseca
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto