Copper-Zinc ratio and nutritional status in colorectal cancer patients during the perioperative period

Autor(es)

de Figueiredo Ribeiro, Sofia Miranda ^[1] ; Tomazini Munhoz Moya, Amanda Maria ^[2] ; Moreno Braga, Camila Bitu ^[1] ; Domenici, Fernanda Aparecida ^[1] ; Feitosa, Marley Ribeiro ^[3] ; Feres, Omar ^[4] ; Ribeiro da Rocha, Jose Joaquim ^[4] ; de Carvalho da Cunha, Selma Freire ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Internal Med, Div Med Nutr, BR-14049 Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo, Ribeirao Preto Med Sch, BR-14049 Ribeirao Preto, SP - Brazil

^[3] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Surg & Anat, Div Coloproctol, BR-14049 Ribeirao Preto, SP - Brazil

^[4] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Surg & Anat, BR-14049 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Acta Cirurgica Brasileira; v. 31, n. 1, p. 24-28, 2016.
• Citações Web of Science: 4

Resumo

PURPOSE: This study aimed to determine Cu/Zn ratio, nutritional and inflammatory status in patients during the perioperative period for colorectal cancer. METHODS: The study included patients with histological diagnosis of colorectal adenocarcinoma (Cancer Group, n=46) and healthy volunteers (Control Group, n=28). We determined habitual food intake, body composition, laboratory data of nutritional status, serum calprotectin and plasma Cu and Zn concentrations. Mann-Whitney U-test was performed between-group comparisons and Spearman correlation test for correlations between the variables. RESULTS: Individuals in the Cancer Group presented significantly lower BMI, fat mass, plasma hemoglobin, total protein and albumin as compared with the Control Group. Serum calprotectin{[}70.1 ng/mL (CI95% 55.8-84.5) vs. 53.3 ng/mL (40.3-66.4), p=0.05], plasma Cu concentrations {[}120 mu g/dL(CI95% 114-126) vs. 106 mu g/dL(CI95% 98-114), p<0.01] and the Cu/Zn ratio {[}1.59 (CI95% 1.48-1.71) vs. 1.35 (CI95% 1.23-1.46), p=0.01] were higher in patients with colorectal cancer than in controls. Additionally, the Cancer Group showed negative correlations between the Cu/Zn ratio and Zn intake, hemoglobin, serum albumin, and positive correlation between the Cu/Zn ratio and serum calprotectin. CONCLUSION: These results indicate that an increased plasma Cu/Zn ratio and serum calprotectin, and decreased protein values may be a result of the systemic inflammatory response to the tumor process. (AU)

• Processo FAPESP: 11/07867-4 - Marcadores de estresse oxidativo após ciclos de quimioterapia adjuvante para câncer de cólon: efeito da suplementação de zinco
• Beneficiário: Selma Freire de Carvalho
• Modalidade de apoio: Auxílio à Pesquisa - Regular