| Full text | |
| Author(s): |
de Figueiredo Ribeiro, Sofia Miranda
[1]
;
Tomazini Munhoz Moya, Amanda Maria
[2]
;
Moreno Braga, Camila Bitu
[1]
;
Domenici, Fernanda Aparecida
[1]
;
Feitosa, Marley Ribeiro
[3]
;
Feres, Omar
[4]
;
Ribeiro da Rocha, Jose Joaquim
[4]
;
de Carvalho da Cunha, Selma Freire
[1]
Total Authors: 8
|
| Affiliation: | [1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Internal Med, Div Med Nutr, BR-14049 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Ribeirao Preto Med Sch, BR-14049 Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Surg & Anat, Div Coloproctol, BR-14049 Ribeirao Preto, SP - Brazil
[4] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Surg & Anat, BR-14049 Ribeirao Preto, SP - Brazil
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | Acta Cirurgica Brasileira; v. 31, n. 1, p. 24-28, 2016. |
| Web of Science Citations: | 4 |
| Abstract | |
PURPOSE: This study aimed to determine Cu/Zn ratio, nutritional and inflammatory status in patients during the perioperative period for colorectal cancer. METHODS: The study included patients with histological diagnosis of colorectal adenocarcinoma (Cancer Group, n=46) and healthy volunteers (Control Group, n=28). We determined habitual food intake, body composition, laboratory data of nutritional status, serum calprotectin and plasma Cu and Zn concentrations. Mann-Whitney U-test was performed between-group comparisons and Spearman correlation test for correlations between the variables. RESULTS: Individuals in the Cancer Group presented significantly lower BMI, fat mass, plasma hemoglobin, total protein and albumin as compared with the Control Group. Serum calprotectin{[}70.1 ng/mL (CI95% 55.8-84.5) vs. 53.3 ng/mL (40.3-66.4), p=0.05], plasma Cu concentrations {[}120 mu g/dL(CI95% 114-126) vs. 106 mu g/dL(CI95% 98-114), p<0.01] and the Cu/Zn ratio {[}1.59 (CI95% 1.48-1.71) vs. 1.35 (CI95% 1.23-1.46), p=0.01] were higher in patients with colorectal cancer than in controls. Additionally, the Cancer Group showed negative correlations between the Cu/Zn ratio and Zn intake, hemoglobin, serum albumin, and positive correlation between the Cu/Zn ratio and serum calprotectin. CONCLUSION: These results indicate that an increased plasma Cu/Zn ratio and serum calprotectin, and decreased protein values may be a result of the systemic inflammatory response to the tumor process. (AU) | |
| FAPESP's process: | 11/07867-4 - Oxidative stress markers after cycles of adjuvant chemotherapy for colon cancer: effect of zinc supplementation |
| Grantee: | Selma Freire de Carvalho |
| Support Opportunities: | Regular Research Grants |