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Oxidative stress markers after cycles of adjuvant chemotherapy for colon cancer: effect of zinc supplementation

Grant number: 11/07867-4
Support type:Regular Research Grants
Duration: October 01, 2011 - September 30, 2013
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal researcher:Selma Freire de Carvalho da Cunha
Grantee:Selma Freire de Carvalho da Cunha
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Assoc. researchers:Camila Bitu Moreno Braga ; Fernanda Maris Peria ; Helio Vannucchi ; Sofia Miranda de Figueiredo Ribeiro


To determine the oxidative stress after cycles of chemotherapy in patients with adjuvant therapy after surgery for colon cancer, with or without zinc supplementation. Subjects: Thirty adults (older than 18 years) from both genders will participate in this study. All patients underwent stage III colon cancer surgical resection and are starting adjuvant chemotherapy with capecitabine and oxaliplatin in HCFMRP- USP. Patients will be randomized into two groups. The first one (QT-Zn Group, n=15) will receive 70 mg/d of zinc orally for 12 weeks and the second one will receive placebo (QT-Placebo Group, n=15). The study will also include 30 healthy volunteers matched for age, gender and socioeconomic status, who will receive 70 mg /d of zinc supplement (C-Zn Group, n=15) or placebo (C-Placebo Group, n=15) for 12 weeks. Methods: The questionnaires about dietary intake (semiquantitative food frequency and food record), fatigue (FACIT-F) and questionnaires that assess the side effects of chemotherapy (CTCAE) will be evaluated. Anthropometry and bioelectrical impedance measurements will be made. Blood collection will be performed before the 1st, 2nd, 3rd and 4th cycles of chemotherapy (median duration of 21 days among cicles). The nutrients involved in oxidative stress (vitamin C and E, zinc and selenium) and markers anti and pro-oxidants (MDA, SOD, GPx and 8-isoprostane) will be determined. The control group will undergo the same procedures, except for chemotherapy. Statistical analysis will be made by the software Statistica 7.0, using ANOVA F-test or by Kruskal - Wallis, according to normality of variables. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE FIGUEIREDO RIBEIRO, SOFIA MIRANDA; TOMAZINI MUNHOZ MOYA, AMANDA MARIA; MORENO BRAGA, CAMILA BITU; DOMENICI, FERNANDA APARECIDA; FEITOSA, MARLEY RIBEIRO; FERES, OMAR; RIBEIRO DA ROCHA, JOSE JOAQUIM; DE CARVALHO DA CUNHA, SELMA FREIRE. Copper-Zinc ratio and nutritional status in colorectal cancer patients during the perioperative period. Acta Cirurgica Brasileira, v. 31, n. 1, p. 24-28, . (11/07867-4)
SOFIA MIRANDA DE FIGUEIREDO RIBEIRO; CAMILA BITU MORENO BRAGA; FERNANDA MARIS PERIA; EDSON ZANGIACOMI MARTINEZ; JOSÉ JOAQUIM RIBEIRO DA ROCHA; SELMA FREIRE CARVALHO CUNHA. Efeitos da suplementação de zinco na fadiga e na qualidade de vida de pacientes com câncer colorretal. Einstein (São Paulo), v. 15, n. 1, p. 24-28, . (11/07867-4)
DE FIGUEIREDO RIBEIRO, SOFIA MIRANDA; MORENO BRAGA, CAMILA BITU; PERIA, FERNANDA MARIS; DOMENICI, FERNANDA APARECIDA; MARTINEZ, EDSON ZANGIACOMI; FERES, OMAR; RIBEIRO DA ROCHA, JOSE JOAQUIM; DE CARVALHO DA CUNHA, SELMA FREIRE. Effect of Zinc Supplementation on Antioxidant Defenses and Oxidative Stress Markers in Patients Undergoing Chemotherapy for Colorectal Cancer: a Placebo-Controlled, Prospective Randomized Trial. BIOLOGICAL TRACE ELEMENT RESEARCH, v. 169, n. 1, p. 8-16, . (11/07867-4)

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