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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Attenuated allergic inflammatory response in the lungs during lactation

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Autor(es):
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Ochoa-Amaya, Julieta E. [1, 2] ; Marino, Larissa P. [3] ; Tobaruela, Carla N. [1] ; Namazu, Lilian B. [1] ; Calefi, Atilio S. [1] ; Margatho, Rafael [1] ; Goncalves, Jr., Vagner [1] ; Queiroz-Hazarbassanov, Nicolle [1] ; Klein, Marianne O. [1] ; Palermo-Neto, Joao [1] ; Ligeiro de Oliveira, Ana P. [4] ; Massoco, Cristina de O. [1] ; Felicio, Luciano F. [1]
Número total de Autores: 13
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Dept Patol, Fac Med Vet, Sao Paulo, SP - Brazil
[2] Univ Llanos, Programa Med Vet & Zootecnia, Fac Ciencias Agr & Recursos Nat, Villavicencio - Colombia
[3] Univ Santo Amaro, Sao Paulo, SP - Brazil
[4] Univ Nove de Julho, Programa Posgrad Biofoton Aplicada Ciencias Saude, Sao Paulo - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: Life Sciences; v. 151, p. 281-287, APR 15 2016.
Citações Web of Science: 2
Resumo

Aims: To evaluate the influence of lactation on lung immune function during allergic inflammation. Main methods: Female rats, 60-90 days old, were divided into three groups: no lung allergy virgins (N group), ovalbumin (OVA)-immunized and sensitized virgins (V group), and OVA-immunized and sensitized lactating females (L group). On gestation day (GD) 10, all animals in L group received a subcutaneous injection of 0.1 mg.kg(-1) OVA plus aluminum hydroxide. On GD17, the L group received a subcutaneous booster injection of 10 mu g OVA plus 10 mg aluminum hydroxide. After 7 days, an inhalatory challenge with 1% OVA was given in 15 min sessions for 3 consecutive days. Animals from the V group received the same treatment, meaning both tests and time intervals between OVA treatment and inhalatory challenge were the same as in the L group. Twenty-four hours after the last inhalation session, the animals were euthanized, and the following tests were performed: total and differential bronchoalveolar lavage (BAL) and femoral marrow lavage (FML) leukocyte counts, quantification of tumor necrosis factor alpha (TNF-alpha) and interferon gamma (IFN-gamma) levels in BAL fluid, and quantification of plasma corticosterone and catecholamine levels. Key findings: The L group presented lower BAL total leukocyte counts and decreases in the number of eosinophils and macrophages compared with the V group. They also expressed higher BAL IFN-gamma and lower plasma corticosterone levels. Plasma norepinephrine levels were higher in the L group than in the N and V groups. Significance: Lactating female rats presented less intense allergic lung inflammation. Our findings suggest that lactation may protect females from asthmatic crises. (C) 2016 Elsevier Inc. All rights reserved. (AU)

Processo FAPESP: 13/01610-7 - Subsistência e reprodução: modulação opioidérgica de comportamentos durante a lactação
Beneficiário:Luciano Freitas Felicio
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 09/51886-3 - Neuroimunomodulação: fármacos, estresse e citocinas nas relações entre os sistemas nervoso, endócrino e imune
Beneficiário:João Palermo Neto
Modalidade de apoio: Auxílio à Pesquisa - Temático