Two alternative estimation procedures for the negative binomial cure rate model with a latent activation scheme

Autor(es)

Gallardo, Diego I. ^[1] ; Bolfarine, Heleno ^[2]

Afiliação do(s) autor(es)

^[1] Univ Antofagasta, Fac Ciencias Basicas, Dept Matemat, Antofagasta - Chile

^[2] Univ Sao Paulo, IME, Dept Estat, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: SORT-Statistics and Operations Research Transactions; v. 40, n. 1, p. 31-54, JAN-JUN 2016.
• Citações Web of Science: 1

Resumo

In this paper two alternative estimation procedures based on the EM algorithm are proposed for the flexible negative binomial cure rate model with a latent activation scheme. The Weibull model as well as the log-normal and gamma distributions are also considered for the time-to-event data for the non-destroyed cells. Simulation studies show the satisfactory performance of the proposed methodology. The impact of misspecifying the survival function on both components of the model (cured and susceptible) is also evaluated. The use of the new methodology is illustrated with a real data set related to a clinical trial on Phase III cutaneous melanoma patients. (AU)

• Processo FAPESP: 13/23684-2 - Estendendo o modelo de cura Destrutivo Binomial Negativo com um esquema de ativação latente.
• Beneficiário: Diego Ignacio Gallardo Mateluna
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado