| Full text | |
| Author(s): |
Total Authors: 2
|
| Affiliation: | [1] Univ Antofagasta, Fac Ciencias Basicas, Dept Matemat, Antofagasta - Chile
[2] Univ Sao Paulo, IME, Dept Estat, Sao Paulo - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | SORT-Statistics and Operations Research Transactions; v. 40, n. 1, p. 31-54, JAN-JUN 2016. |
| Web of Science Citations: | 1 |
| Abstract | |
In this paper two alternative estimation procedures based on the EM algorithm are proposed for the flexible negative binomial cure rate model with a latent activation scheme. The Weibull model as well as the log-normal and gamma distributions are also considered for the time-to-event data for the non-destroyed cells. Simulation studies show the satisfactory performance of the proposed methodology. The impact of misspecifying the survival function on both components of the model (cured and susceptible) is also evaluated. The use of the new methodology is illustrated with a real data set related to a clinical trial on Phase III cutaneous melanoma patients. (AU) | |
| FAPESP's process: | 13/23684-2 - Extending the Destructive Negative Binomial cure rate model with a latent activation scheme. |
| Grantee: | Diego Ignacio Gallardo Mateluna |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |