Sevoflurane preconditioning during myocardial ischemia-reperfusion reduces infarct size and preserves autonomic control of circulation in rats

Autor(es)

Pasqualin, Rubens Campana ^[1] ; Mostarda, Cristiano Teixeira ^[2] ; de Souza, Leandro Ezequiel ^[2] ; Vane, Matheus Fachini ^[3] ; Sirvente, Raquel ^[2] ; Otsuki, Denise Aya ^[4] ; Abramides Torres, Marcelo Luis ^[4] ; Costa Irigoyen, Maria Claudia ^[5] ; Costa Auler, Jose Otavio ^[4]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Fac Med, Hosp Clin, Hypertens Unit, Expt Div, Inst Coracao InCor, Sao Paulo, SP - Brazil

^[3] Univ Sao Paulo, Fac Med, Anesthesiol, Lab Anesthesiol LIM 08, Sao Paulo, SP - Brazil

^[4] Univ Sao Paulo, Fac Med, Lab Anesthesiol LIM 08, Ave Dr Arnaldo 455, BR-01246903 Sao Paulo, SP - Brazil

^[5] Univ Sao Paulo, Hosp Clin, Hypertens Unit, Expt Div, Inst Coracao InCor, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Acta Cirurgica Brasileira; v. 31, n. 5, p. 338-345, MAY 2016.
• Citações Web of Science: 5

Resumo

PURPOSE: To investigate the myocardial ischemia-reperfusion with sevoflurane anesthetic preconditioning (APC) would present beneficial effects on autonomic and cardiac function indexes after the acute phase of a myocardial ischemia-reperfusion. METHODS: Twenty Wistar rats were allocated in three groups: control (CON, n=10), myocardial infarction with sevoflurane (SEV, n=5) and infarcted without sevoflurane (INF, n=5). Myocardial ischemia (60 min) and reperfusion were performed by temporary coronary occlusion. Twenty-one days later, the systolic and diastolic function were evaluated by echocardiography; spectral analysis of the systolic arterial pressure (SAPV) and heart rate variability (HRV) were assessed. After the recording period, the infarct size (IS) was evaluated. RESULTS: The INF group presented greater cardiac dysfunction and increased sympathetic modulation of the SAPV, as well as decreased alpha index and worse vagal modulation of the HRV. The SEV group exhibited attenuation of the systolic and diastolic dysfunction and preserved vagal modulation (square root of the mean squared differences of successive R-R intervals and high frequency) of HRV, as well as a smaller IS. CONCLUSION: Sevoflurane preconditioning better preserved the cardiac function and autonomic modulation of the heart in post-acute myocardial infarction period. (AU)

• Processo FAPESP: 06/55220-1 - Estudo do efeito protetor do sevoflurano, propofol e sufentanil sobre o miocardio na lesao de isquemia e reperfusao. estudo experimental em ratos.
• Beneficiário: José Otávio Costa Auler Junior
• Modalidade de apoio: Auxílio à Pesquisa - Regular