Green tea glycolic extract-loaded liquid crystal systems: development, characterization and microbiological control

Autor(es)

Bernegossi, Jessica ; Cunha Barbosa, Raquel Maria ; Rustice, Patricia Maciel ; Chorilli, Marlus

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Journal of Pharmaceutical Sciences; v. 52, n. 3, p. 383-390, JUL-SEP 2016.
• Citações Web of Science: 1

Resumo

ABSTRACT Liquid crystal systems (LCSs) have interesting cosmetic applications because of their ability to increase the therapeutic efficiency and solubility of active ingredients. The aim of the present research was to develop green tea glycolic extract-loaded LCSs, to characterize and to perform microbiological control. The ternary phase diagram was constructed using polysorbate 20, silicone glycol copolymer (SGC) - DC 193(r), and distilled water with 1.5% glycolic green tea extract. The systems were characterized by polarized light microscopy. Formulations selected were characterized as transparent viscous systems and transparent liquid system indicated mesophases lamellar structure. The results of the microbiological analysis of mesophilic aerobic microorganisms (bacteria and fungi) revealed that the above formulation showed a biologic load <10 CFU/mL in all samples. In conclusion, liquid crystalline systems that have presented formation of a lamellar mesophases were developed. Furthermore, the formulation and products tested presented the adequate microbiological quality in accordance with official recommendations. (AU)

• Processo FAPESP: 10/17037-6 - Avaliação do potencial de sistemas nanoestruturados estabilizados com poliéter funcional siloxano para administração cutânea de metotrexato
• Beneficiário: Marlus Chorilli
• Modalidade de apoio: Auxílio à Pesquisa - Regular