Green tea glycolic extract-loaded liquid crystal systems: development, characterization and microbiological control

Author(s)

Bernegossi, Jessica ; Cunha Barbosa, Raquel Maria ; Rustice, Patricia Maciel ; Chorilli, Marlus

• Document type: Journal article
• Source: Brazilian Journal of Pharmaceutical Sciences; v. 52, n. 3, p. 383-390, JUL-SEP 2016.
• Web of Science Citations: 1

Abstract

ABSTRACT Liquid crystal systems (LCSs) have interesting cosmetic applications because of their ability to increase the therapeutic efficiency and solubility of active ingredients. The aim of the present research was to develop green tea glycolic extract-loaded LCSs, to characterize and to perform microbiological control. The ternary phase diagram was constructed using polysorbate 20, silicone glycol copolymer (SGC) - DC 193(r), and distilled water with 1.5% glycolic green tea extract. The systems were characterized by polarized light microscopy. Formulations selected were characterized as transparent viscous systems and transparent liquid system indicated mesophases lamellar structure. The results of the microbiological analysis of mesophilic aerobic microorganisms (bacteria and fungi) revealed that the above formulation showed a biologic load <10 CFU/mL in all samples. In conclusion, liquid crystalline systems that have presented formation of a lamellar mesophases were developed. Furthermore, the formulation and products tested presented the adequate microbiological quality in accordance with official recommendations. (AU)

• FAPESP's process: 10/17037-6 - Evaluation of the potential of nanostructured systems stabilized with polyether functional siloxane for cutaneous administration of methotrexate
• Grantee: Marlus Chorilli
• Support Opportunities: Regular Research Grants