Development of a two-dimensional extraction, separation and analysis system for evaluating the bioactivity of phytochemicals

• Grant number: 18/14582-5
• Support Opportunities: Research Grants - Young Investigators Grants - Phase 2
• Start date: May 01, 2019
• End date: April 30, 2025
• Field of knowledge: Agronomical Sciences - Food Science and Technology - Food Engineering
• Principal Investigator: Maurício Ariel Rostagno
• Grantee: Maurício Ariel Rostagno
• Host Institution: Faculdade de Ciências Aplicadas (FCA). Universidade Estadual de Campinas (UNICAMP). Limeira , SP, Brazil
• Associated researchers: Adriane Elisabete Antunes de Moraes ; Ana Carolina de Aguiar ; Augusto Ducati Luchessi ; Diogo Thimoteo da Cunha ; Fernando Moreira Simabuco ; Julian Martínez ; Rosângela Maria Neves Bezerra ; Tânia Forster Carneiro
• Associated research grant: 13/04304-4 - Development of integrated systems for the analysis of bioactive compounds in natural products employing supercritical technology, AP.JP
• Associated research grant(s): 23/07411-8 - VI Iberoamerican Conference on Supercritical Fluids (PROSCIBA 2023), AR.EXT; 19/13496-0 - Multi user equipment approved in grant 2018/14582-5: ultra-high pressure liquid chromatography system (UHPLC), composed by a quaternary pump, autoinjector, oven with selection valve and detector (PDA), AP.EMU
• Associated scholarship(s): 23/03439-5 - Extraction, separation and two-dimensional analysis of phenolic compounds from agro-industry residues with antimicrobial potential against Staphylococcus aureus for application in curatives., BP.PD; 23/12744-6 - EVALUATION OF THE THERMOSONICATION PROCESS FOR EXTRACTION OF CAFFEINE AND CHLOROGENIC ACID FROM COFFEE RESIDUE USING ALTERNATIVE SOLVENTS, BP.IC; 23/11025-6 - Development of extraction methods, separation and two-dimensional analysis of phenolic compounds in natural products, BP.PD; + associated scholarships 23/05097-4 - Development of extraction methods, separation and two-dimensional analysis of phenolic compounds in natural products, BP.PD; 22/10469-5 - Application of in silico tools for the extraction of bioactive compounds from agro by-products by gas-expanded liquids and green switchable solvents, BP.PD; 21/12264-9 - A techno-economic evaluation of emerging technologies and green solvents coupling to the two-dimensional system of extraction, separation and analysis to obtain phenolic compounds from waste of the coffee and plant-based beverages industry, BP.PD; 21/13638-0 - Development of active packaging through the extraction of bioactive compounds from pomegranate peel (Punica granatum L.), BP.MS; 20/15774-5 - Development of methods of extraction, separation and two-dimensional analysis of phenolic compounds in natural products, BP.PD; 20/04067-6 - Evaluation of ultrasound-assisted pressurized fluid extraction coupled with solid phase extraction for extracting phenolic compounds and terpenes from rosemary (Rosmarinus officinalis) and sage (Salvia officinalis), BP.DD; 20/08421-9 - Application of non-volatile alternative solvents to create sustainable two-dimensional and integrated platforms for harnessing agro-industrial waste from jaboticaba and pomegranate fruits, BP.PD; 20/03623-2 - Extraction and separation of phenolic compounds from green propolis by a bidimensional system, BP.DD; 19/24537-0 - Phytochemical evaluation of apple (Malus domestica) industrial residue from extraction and separation by a two-dimensional system, BP.DD - associated scholarships

Abstract

This research project proposes the development of a two-dimensional extraction, separation and analysis system (PLEgrad-SPE x UHPLC) by coupling extraction with gradient pressurized liquids (PLEgrad) with solid phase extraction (SPE) in the first dimension and orthogonally with ultra-high pressure chromatography (UHPLC) in the second dimension. The objective is to develop a system that allows the characterization of the chemical composition of natural raw materials in a fast, efficient and with real-time monitoring, while allowing the production of small quantities of extracts obtained through the fractionation of the present compounds. These fractions should be well characterized chemically and with low contamination between them. The system will be validated with several samples, including soybean (Glycine max), Brazilian ginseng (Pfaffia glomerata), black tea and green tea (Camellia sinensis), mate (Ilex paraguariensis), coffee (Coffea arabica), pomegranate granatum), orange peel (Citrus sinensis), sicilian lemon peel (Citrus x limon) apple peel (Malus domestica), jabuticaba bark (Myrciaria cauliflora), rosemary (Rosmarinus officinalis) and sage (Salvia officinalis). Initially the rapid UHPLC analysis methods will be developed that will be used in the second separation dimension. Several analysis conditions (temperature, column size, flow, volume and injection solvent and mobile phase composition) will be evaluated for an ultra-fast separation method (time between samples <2.0 min). Subsequently, different extraction conditions will be evaluated by SPE coupled gradient PLE, including temperature, pressure, sample amount, adsorbent type, flow, solvent and duration of the extraction / elution gradient. This proposal consists of a continuation of the Young Researcher project (FAPESP 2013 / 04304-4), seeking to consolidate this line of research at FCA / UNICAMP and to continue the training of qualified human resources. (AU)

Scientific publications

(69)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BARROSO, TIAGO; SGANZERLA, WILLIAM; ROSA, RAFAEL; CASTRO, LUIZ; MACIEL-SILVA, FRANCISCO; ROSTAGNO, MAURICIO; FORSTER-CARNEIRO, TANIA. Semi-continuous flow-through hydrothermal pretreatment for the recovery of bioproducts from jabuticaba (Myrciaria cauliflora) agro-industrial by-product. Food Research International, v. 158, p. 12-pg., 2022-06-28. (20/16248-5, 18/14582-5, 21/04096-9, 19/26925-7)

BAIAO DIAS, ARTHUR LUIZ; DE AGUIAR, ANA CAROLINA; ROSTAGNO, MAURICIO A.. Extraction of natural products using supercritical fluids and pressurized liquids assisted by ultrasound: Current status and trends. ULTRASONICS SONOCHEMISTRY, v. 74, JUN 2021. (18/14582-5)

DA SILVA, LAISE C.; SOUZA, MARIANA C.; SUMERE, BEATRIZ R.; SILVA, LUIZ G. S.; DA CUNHA, DIOGO T.; BARBERO, GERARDO F.; BEZERRA, ROSANGELA M. N.; ROSTAGNO, MAURICIO A.. Simultaneous extraction and separation of bioactive compounds from apple pomace using pressurized liquids coupled on-line with solid-phase extraction. Food Chemistry, v. 318, JUL 15 2020. (18/14582-5, 16/19930-6, 18/17089-8, 19/24537-0)

COSTA, JOSIEL MARTINS; STRIEDER, MONIQUE MARTINS; SALDANA, MARLENY D. A.; ROSTAGNO, MAURICIO ARIEL; FORSTER-CARNEIRO, TANIA. Recent Advances in the Processing of Agri-food By-products by Subcritical Water. Food and Bioprocess Technology, v. N/A, p. 20-pg., 2023-04-01. (18/14582-5, 18/14938-4, 21/12264-9, 21/03950-6)

NOCHI CASTRO, LUIZ EDUARDO; SGANZERLA, WILLIAM GUSTAVO; CRUZ TABOSA BARROSOA, TIAGO LINHARES; MACIEL-SILVA, FRANCISCO WESHLEY; SARAGIOTTO COLPINI, LEDA MARIA; STIVAL BITTENCOURT, PAULO RODRIGO; ROSTAGNO, MAURICIO A.; FORSTER-CARNEIRO, TANIA. Improving the semi-continuous flow-through subcritical water hydrolysis of grape pomace (Vitis vinifera L.) by pH and temperature control. JOURNAL OF SUPERCRITICAL FLUIDS, v. 196, p. 14-pg., 2023-02-28. (21/04096-9, 18/14582-5, 18/14938-4, 19/26925-7, 20/16248-5)

LACHOS-PEREZ, DANIEL; BASEGGIO, ANDRESSA M.; TORRES-MAYANGA, PAULO C.; AVILA, PATRICIA F.; TOMPSETT, G. A.; MAROSTICA, MARIO; GOLDBECK, ROSANA; TIMKO, MICHAEL T.; ROSTAGNO, MAURICIO; MARTINEZ, JULIAN; et al. Sequential subcritical water process applied to orange peel for the recovery flavanones and sugars. JOURNAL OF SUPERCRITICAL FLUIDS, v. 160, JUN 1 2020. (18/14582-5, 18/05999-0, 11/19817-1, 16/04602-3)

OLIVEIRA, T. C. G.; INTERLANDI, M. A.; HANLON, K. E.; TORRES-MAYANGA, P. C.; SILVELLO, M. A. C.; TIMKO, M. T.; ROSTAGNO, M. A.; GOLDBECK, R.; FORSTER-CARNEIRO, T.. Integration of Subcritical Water and Enzymatic Hydrolysis to Obtain Fermentable Sugars and Second-Generation Ethanol from Sugarcane Straw. BioEnergy Research, v. 15, n. 2, p. 12-pg., 2021-04-17. (19/08542-3, 18/05999-0, 18/14582-5, 13/04304-4, 18/14938-4)

MACIEL-SILVA, FRANCISCO W.; VIGANO, JULIANE; CASTRO, LUIZ E. N.; SGANZERLA, WILLIAM GUSTAVO; BULLER, LUZ SELENE; MARTINEZ, JULIAN; ROSTAGNO, MAURICIO A.; FORSTER-CARNEIRO, TANIA. Pressurized liquid extraction coupled in-line with SPE and on-line with HPLC (PLE-SPExHPLC) for the recovery and purification of anthocyanins from SC-CO2 semi-defatted Acai (Euterpe oleracea). Food Research International, v. 160, p. 11-pg., 2022-07-26. (20/10323-5, 20/15774-5, 18/14938-4, 18/05999-0, 19/26925-7, 18/14582-5)

TORRES-MAYANGA, PAULO. C. C.; CASTRO, LUIZ E. N.; AZAMBUJA, SUELLEN P. H.; LACHOS-PEREZ, DANIEL; BROWN, AVERY. B. B.; TIMKO, MICHAEL. T. T.; GOLDBECK, ROSANA; FORSTER-CARNEIRO, TANIA; ROSTAGNO, MAURICIO. A. A.. Detoxification of furanic aldehydes of the hemicellulosic hydrothermal hydrolysate of brewers' spent grains by continuous adsorption on a fixed-bed column. BIOFUELS BIOPRODUCTS & BIOREFINING-BIOFPR, v. N/A, p. 14-pg., 2023-02-10. (21/04096-9, 20/10323-5, 18/14938-4, 18/05999-0, 18/14582-5)

CHAVES, JAISA O.; SANCHES, VITOR L.; VIGANO, JULIANE; MESQUITA, LEONARDO M. DE SOUZA; DE SOUZA, MARIANA C.; DA SILVA, LAISE C.; ACUNHA, TANIZE; FACCIOLI, LUCIA H.; ROSTAGNO, MAURICIO A.. Integration of pressurized liquid extraction and in-line solid-phase extraction to simultaneously extract and concentrate phenolic compounds from lemon peel (Citrus limon L.). Food Research International, v. 157, p. 12-pg., 2022-07-01. (13/04304-4, 20/08421-9, 15/00658-1, 19/13496-0, 18/14582-5, 20/15774-5)

MACIEL-SILVA, FRANCISCO W.; BULLER, LUZ S.; GONCALVES, MARIA L. M. B. B.; ROSTAGNO, MAURICIO A.; FORSTER-CARNEIRO, TANIA. ustainable development in the Legal Amazon: energy recovery from acai seed. BIOFUELS BIOPRODUCTS & BIOREFINING-BIOFPR, v. 15, n. 4, p. 1174-1189, JUL 2021. (18/14582-5, 18/14938-4, 20/10323-5, 18/05999-0)

MESQUITA, LEONARDO M. DE SOUZA; CONTIERI, LETICIA S.; SANCHES, VITOR L.; KAMIKAWACHI, RENAN; SOSA, FILIPE H. B.; VILEGAS, WAGNER; ROSTAGNO, MAURICIO A.. Fast and green universal method to analyze and quantify anthocyanins in natural products by UPLC-PDA. Food Chemistry, v. 428, p. 11-pg., 2023-12-01. (21/11022-1, 18/14582-5, 20/08421-9, 19/13496-0, 20/03623-2, 21/11023-8)

CONTIERI, LETICIA S.; MESQUITA, LEONARDO M. DE SOUZA; SANCHES, VITOR L.; VIGANO, JULIANE; KAMIKAWACHI, RENAN CANUTE; VILEGAS, WAGNER; ROSTAGNO, MAURICIO A.. Ultra-high-performance liquid chromatography using a fused-core particle column for fast analysis of propolis phenolic compounds. JOURNAL OF SEPARATION SCIENCE, v. 46, n. 3, p. 12-pg., 2022-12-09. (18/14582-5, 19/13496-0, 20/08421-9, 20/15774-5)

VIGANO, JULIANE; STRIEDER, MONIQUE MARTINS; PIZANI, RODRIGO S.; CONTIERI, LETICIA S.; MESQUITA, LEONARDO M. DE SOUZA; ROSTAGNO, MAURICIO A.. Application of an integrative system (2D PLExHPLC-PDA) for bioactive compound extraction and online quantification: Advantages, validation, and considerations. Analytica Chimica Acta, v. 1272, p. 9-pg., 2023-06-15. (18/14582-5, 20/08421-9, 20/15774-5, 19/13496-0, 21/12264-9, 20/03623-2, 20/04067-6)

BARROSO, TIAGO LINHARES CRUZ TABOSA; SGANZERLA, WILLIAM GUSTAVO; CASTRO, LUIZ EDUARDO NOCHI; FREIRIA, NICOLAS LUIS MOREIRA; BARBERO, GERARDO FERNANDEZ; LOVILLO, MIGUEL PALMA; ROSTAGNO, MAURICIO ARIEL; FORSTER-CARNEIRO, TANIA. Removal of 5-hydroxymethylfurfural from brewer's spent grains hydrolysates obtained by subcritical water hydrolysis: An approach using liquid-liquid extraction. JOURNAL OF SUPERCRITICAL FLUIDS, v. 201, p. 9-pg., 2023-06-13. (21/04096-9, 18/14582-5, 18/14938-4, 20/16248-5, 19/26925-7)

DE SOUZA MESQUITA, LEONARDO M.; CONTIERI, LETICIA S.; SOSA, FILIPE H. B.; PIZANI, RODRIGO S.; CHAVES, JAISA; VIGANO, JULIANE; VENTURA, SONIA P. M.; ROSTAGNO, MAURICIO A.. Combining eutectic solvents and pressurized liquid extraction coupled in-line with solid-phase extraction to recover, purify and stabilize anthocyanins from Brazilian berry waste. GREEN CHEMISTRY, v. 25, n. 5, p. 14-pg., 2023-02-21. (21/11022-1, 18/14582-5, 20/08421-9, 20/15774-5, 19/13496-0, 20/03623-2, 21/11023-8, 20/04067-6)

DE OLIVEIRA, ISADORA LOPES; DOMINGUEZ-RODRIGUEZ, GLORIA; MONTERO, LIDIA; VIGANO, JULIANE; CIFUENTES, ALEJANDRO; ROSTAGNO, MAURICIO ARIAL; IBANEZ, ELENA. Advanced Extraction Techniques Combined with Natural Deep Eutectic Solvents for Extracting Phenolic Compounds from Pomegranate (Punica granatum L.) Peels. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 25, n. 18, p. 16-pg., 2024-09-01. (22/13565-5, 18/14582-5, 21/13638-0)

DE FREITAS MARINHO, LEONARDO; SGANZERLA, WILLIAM GUSTAVO; VELASQUEZ, JEAN AGUSTIN; DA SILVA, ALINE PRISCILLA GOMES; ROSTAGNO, MAURICIO ARIEL; FORSTER-CARNEIRO, TANIA. A bibliometric analysis of phenolic acids over the last five years. BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY, v. 56, p. 13-pg., 2024-02-02. (19/26925-7, 18/14938-4, 22/11690-7, 21/08696-0, 18/14582-5)

SANCHES, VITOR L.; STRIEDER, MONIQUE MARTINS; BREITKREITZ, MARCIA CRISTINA; BEZERRA, ROSANGELA MARIA NEVES; CHAVES, JAISA O.; DE OLIVEIRA, ISADORA LOPES; MESQUITA, LEONARDO M. DE SOUZA; VIGANO, JULIANE; CONTIERI, LETICIA SANCHES; PIZANI, RODRIGO STEIN; et al. Pressurized liquid extraction assisted by high-intensity ultrasound to obtain hesperidin from lime waste: Integration of in-line purification and on-line chromatographic analysis. Food Research International, v. 182, p. 9-pg., 2024-02-28. (20/08421-9, 19/24537-0, 20/03623-2, 19/13496-0, 21/13638-0, 18/14582-5)

MUSSAGY, CASSAMO U.; MESQUITA, LEONARDO M. DE SOUZA; ROSTAGNO, MAURICIO A.; HADDAD, FELIPE F.; DOS SANTOS, JEAN L.; SCARIM, CAUE B.; HERCULANO, RONDINELLI D.; VALETTE, JEREMY; SANGARE, DIAKARIDIA. Eco-sustainable biorefinery to the management of winery waste by integrating sequential ready-to-use pigments and bioenergy through advanced multi-step kinetic slow pyrolysis. INDUSTRIAL CROPS AND PRODUCTS, v. 221, p. 12-pg., 2024-08-08. (19/13496-0, 18/14582-5, 20/08421-9)

MESQUITA, LEONARDO M. DE SOUZA; VIGANO, JULIANE; VEGGI, PRISCILLA; CONTIERI, LETICIA S.; SOSA, FILIPE H. B.; DE ROSSO, VERIDIANA VERA; VENTURA, SONIA P. M.; ROSTAGNO, MAURICIO A.. Techno-Economic analysis of an efficient anthocyanin extraction process from grape pomace using eutectic solvents ― A critical panorama regarding drying techniques and reusability of solvents. Separation and Purification Technology, v. 347, p. 9-pg., 2024-04-26. (20/15774-5, 21/11022-1, 20/08421-9, 20/03623-2, 19/13496-0, 16/18910-1, 21/11023-8, 18/14582-5)

MARTINS STRIEDER, MONIQUE; MENDIOLA, JOSE; COKDINLEYEN, MELIS; VALDES, ALBERTO; BRAGAGNOLO, FELIPE SANCHEZ; BALBINOT FILHO, CLOVIS A.; LANZA, MARCELO; SALVADOR FERREIRA, SANDRA REGINA; CIFUENTES, ALEJANDRO; ROSTAGNO, MAURICIO ARIEL; et al. Sustainable valorization of almond and peanut plant-based milk cakes: The use of terpenoid mixtures as ready-to-use solvents to enhance supercritical CO₂ extraction. Food Chemistry, v. 479, p. 10-pg., 2025-07-01. (21/12264-9, 18/14582-5, 22/10469-5, 23/12621-1, 19/13496-0, 23/05722-6)

SILVA, CAMILA TELLES; DA SOUZA, MARIANA CORREA; DA FONSECA MACHADO, ANA PAULA; DO NASCIMENTO, ROBERTO DE PAULA; DA CUNHA, DIOGO THIMOTEO; NEVES BEZERRA, ROSANGELA MARIA; ROSTAGNO, MAURICIO ARIEL. Thermal stability and sensory evaluation of a bioactive extract from roasted coffee (Coffea arabica) beans added at increasing concentrations to conventional bread. JOURNAL OF FOOD PROCESSING AND PRESERVATION, v. 45, n. 11, SEP 2021. (18/14582-5, 16/19930-6, 17/23657-6, 13/04304-4, 18/17089-8)

SANCHES, VITOR L.; DE SOUZA MESQUITA, LEONARDO M.; VIGANO, JULIANE; CONTIERI, LETICIA S.; PIZANI, RODRIGO; CHAVES, JAISA; DA SILVA, LAISE CAPELASSO; DE SOUZA, MARIANA CORREA; BREITKREITZ, MARCIA CRISTINA; ROSTAGNO, MAURICIO A.. Insights on the Extraction and Analysis of Phenolic Compounds from Citrus Fruits: Green Perspectives and Current Status. CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY, v. N/A, p. 27-pg., 2022-08-16. (18/14582-5, 20/15774-5, 19/13496-0, 19/24537-0, 20/08421-9, 20/03623-2)

SANTANA, IGOR M.; ROSTAGNO, MAURICIO A.; BREITKREITZ, MARCIA C.. Analytical quality-by-design (AQbD) approach for comprehensive analysis of bioactive compounds from Citrus peel wastes by UPLC. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, v. 415, n. 18, p. 12-pg., 2023-02-28. (18/14582-5)

CHAVES, JAISA OLIVEIRA; DE SOUZA, MARIANA CORREA; DA SILVA, LAISE CAPELASSO; LACHOS-PEREZ, DANIEL; TORRES-MAYANGA, PAULO CESAR; MACHADO, ANA PAULA DA FONSECA; FORSTER-CARNEIRO, TANIA; VAZQUEZ-ESPINOSA, MERCEDES; GONZALEZ-DE-PEREDO, ANA VELASCO; BARBERO, GERARDO FERNANDEZ; et al. Extraction of Flavonoids From Natural Sources Using Modern Techniques. RONTIERS IN CHEMISTR, v. 8, p. 25-pg., 2020-09-25. (18/17089-8, 18/05999-0, 18/14582-5, 16/19930-6, 18/14938-4)

FRONER-LACERDA, LUANA R. R.; SGANZERLA, WILLIAM GUSTAVO; LACERDA, VINICIUS F.; SILLERO, LEONOR; SOLERA, ROSARIO; PEREZ, MONTSERRAT; FORSTER-CARNEIRO, TANIA. Design, fabrication, automation, and scaleup of anaerobic reactors for waste management and bioenergy recovery. BIOFUELS BIOPRODUCTS & BIOREFINING-BIOFPR, v. 18, n. 5, p. 14-pg., 2024-03-14. (18/14582-5)

FRANCISCO, ANA PAULA; SGANZERLA, WILLIAM GUSTAVO; CASTRO, LUIZ EDUARDO NOCHI; BARROSO, TIAGO LINHARES CRUZ TABOSA; DA SILVA, ALINE PRISCILLA GOMES; DA ROSA, CLEONICE GONCALVES; NUNES, MICHAEL RAMOS; FORSTER-CARNEIRO, TANIA; ROSTAGNO, MAURICIO A.. Pressurized liquid extraction of bioactive compounds from grape peel and application in pH-sensing carboxymethyl cellulose films: A promising material to monitor the freshness of pork and milk. Food Research International, v. 179, p. 12-pg., 2024-01-19. (19/26925-7, 21/04096-9, 20/16248-5, 18/14582-5)

CHAVES, JAISA O.; MESQUITA, LEONARDO M. DE SOUZA; STRIEDER, MONIQUE M.; CONTIERI, LETICIA S.; PIZANI, RODRIGO S.; SANCHES, VITOR L.; VIGANO, JULIANE; BEZERRA, ROSANGELA M. NEVES; ROSTAGNO, MAURICIO A.. Eco-friendly and high-performance extraction of flavonoids from lemon peel wastes by applying ultrasound-assisted extraction and eutectic solvents. SUSTAINABLE CHEMISTRY AND PHARMACY, v. 39, p. 13-pg., 2024-06-01. (20/15774-5, 15/00658-1, 20/08421-9, 13/04304-4, 19/13496-0, 19/13496-0, 18/14582-5)

MESQUITA, LEONARDO M. DE SOUZA; CONTIERI, LETICIA S.; A. E SILVA, FRANCISCA; BAGINI, RAFAEL HENRIQUE; BRAGAGNOLO, FELIPE S.; STRIEDER, MONIQUE M.; SOSA, FILIPE H. B.; SCHAEFFER, NICOLAS; FREIRE, MARA G.; VENTURA, SONIA P. M.; et al. Path2Green: introducing 12 green extraction principles and a novel metric for assessing sustainability in biomass valorization. GREEN CHEMISTRY, v. 26, n. 19, p. 21-pg., 2024-08-12. (20/15774-5, 21/11022-1, 15/00658-1, 20/08421-9, 13/04304-4, 23/12621-1, 22/10469-5, 20/03623-2, 19/13496-0, 21/11023-8, 21/12264-9, 18/14582-5, 23/05722-6)

BARROSO, TIAGO LINHARES CRUZ TABOSA; CASTRO, LUIZ EDUARDO NOCHI; DE SOUZA MESQUISTA, LEONARDO M.; BARBERO, GERARDO FERNANDEZ; CARRERA, CEFERINO; ROSTAGNO, MAURICIO ARIEL; FORSTER-CARNEIRO, TANIA. Simple procedure for the simultaneous extraction and purification of anthocyanins using a jabuticaba byproduct biosorbent. Journal of Food Composition and Analysis, v. 130, p. 10-pg., 2024-03-29. (18/14938-4, 22/02039-0, 21/04096-9, 20/16248-5, 18/14582-5)

KESHMIRSHEKAN, ABOLFAZL; MESQUITA, LEONARDO M. DE SOUZA; VENTURA, SONIA P. M.. Biocontrol manufacturing and agricultural applications of Bacilus velezensis. TRENDS IN BIOTECHNOLOGY, v. 42, n. 8, p. 16-pg., 2024-08-07. (21/11022-1, 19/13496-0, 18/14582-5, 20/08421-9)

BARROSO, TIAGO LINHARES CRUZ TABOSA; CASTRO, LUIZ EDUARDO NOCHI; LIMA, JOSE ROMUALDO DE SOUSA; COLPINI, LEDA MARIA SARAGIOTTO; ROSTAGNO, MAURICIO ARIEL; FORSTER-CARNEIRO, TANIA. Synthesis and Optimization of biosorbent using jabuticaba peel (Myrciaria cauliflora) for anthocyanin recovery through adsorption. ADSORPTION-JOURNAL OF THE INTERNATIONAL ADSORPTION SOCIETY, v. 30, n. 6, p. 21-pg., 2024-05-18. (20/16248-5, 18/14582-5, 21/04096-9)

OLIVEIRA, T. C. G.; HANLON, K. E.; INTERLANDI, M. A.; TORRES-MAYANGA, P. C.; SILVELLO, M. A. C.; LACHOS-PEREZ, D.; TIMKO, M. T.; ROSTAGNO, M. A.; GOLDBECK, R.; FORSTER-CARNEIRO, T.. Subcritical water hydrolysis pretreatment of sugarcane bagasse to produce second generation ethanol. JOURNAL OF SUPERCRITICAL FLUIDS, v. 164, OCT 1 2020. (18/14582-5, 18/14938-4, 18/05999-0, 19/08542-3)

SOUZA, MARIANA C.; SILVA, LAISE C.; CHAVES, JAISA O.; SALVADOR, MAYARA P.; SANCHES, VITOR L.; DA CUNHA, DIOGO T.; CARNEIRO, TANIA FOSTER; ROSTAGNO, MAURICIO A.. Simultaneous extraction and separation of compounds from mate (Ilex paraguariensis) leaves by pressurized liquid extraction coupled with solid-phase extraction and in-line UV detection. FOOD CHEMISTRY: MOLECULAR SCIENCES, v. 2, p. 11-pg., 2021-07-30. (19/24537-0, 18/14582-5, 13/04304-4, 16/19930-6)

FERREIRA, VANESSA COSME; AMPESE, LARISSA CASTRO; SGANZERLA, WILLIAM GUSTAVO; COLPINI, LEDA MARIA SARAGIOTTO; FORSTER-CARNEIRO, TANIA. An updated review of recent applications and future perspectives on the sustainable valorization of pitaya (Hylocereus spp.) by- products. SUSTAINABLE CHEMISTRY AND PHARMACY, v. 33, p. 18-pg., 2023-06-01. (18/14582-5, 22/02305-2)

DA SILVA, LAISE C.; VIGANO, JULIANE; DE SOUZA MESQUITA, LEONARDO M.; BAIAO DIAS, ARTHUR L.; DE SOUZA, MARIANA C.; SANCHES, VITOR L.; CHAVES, JAISA O.; PIZANI, RODRIGO S.; CONTIERI, LETICIA S.; ROSTAGNO, MAURICIO A.. Recent advances and trends in extraction techniques to recover polyphenols compounds from apple by-products. FOOD CHEMISTRY-X, v. 12, DEC 30 2021. (20/08421-9, 20/03623-2, 19/24537-0, 20/15774-5, 19/18772-6, 19/13496-0, 18/17089-8, 20/04067-6, 18/14582-5)

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Filed patent(s) as a result of this research project