| Texto completo | |
| Autor(es): |
Carvalho, Jr., Paulo S.
;
Ellena, Javier
;
Yufit, Dmitry S.
;
Howard, Judith A. K.
Número total de Autores: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Crystal Growth & Design; v. 16, n. 7, p. 3875-3883, JUL 2016. |
| Citações Web of Science: | 11 |
| Resumo | |
Polymorphism in racemic pharmaceutical compounds is relatively unexplored. However, this phenomenon may provide an additional tool to crystal engineering, opening the doors to rational design of chiral resolution, chiral enrichment, and chiral purification of pharmaceutical compounds. In this work we report two racemic polymorphs occurring for the nitrate salt of the antidepressant drug fluoxetine (FLX): a racemate (P2(1)/n, Z = 4, Z' = 1) and a kryptoracemate (Pca2(1), Z = 4, Z' = 2). The relative stability of these polymorphs was established through a combination of techniques, namely, differential scanning calorimetric (DSC), thermogravimetric analysis (TGA), hot stage microscopy (HSM), and solubility measurements. Though the two polymorphs share some structural features, the N+-H center dot center dot center dot O- hydrogen bonds have created dissimilar racemic motifs in their packing, resulting in different enantiomer orientations. The racemate is more stable over the temperature ranges we studied and is monotropically related to kryptoracemate. In our experiments, the obtaining of non-centrosymmetric lattice of racemic fluoxetine nitrate was shown to be dependent on kinetic factors. The thermodynamic relationships between both polymorphs were further confirmed by measuring their water solubility at 20 and 37 degrees C. (AU) | |
| Processo FAPESP: | 12/05616-7 - Caracterização no estado sólido de fármacos de ação anti-convulsionantes e antidepressivos: Planejamento de novas formas cristalinas. |
| Beneficiário: | Paulo de Sousa Carvalho Júnior |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 14/12429-4 - Desenvolvimento, avaliação e caracterização de novas formas sólidas de inibidores seletivos de recaptação de serotonina |
| Beneficiário: | Paulo de Sousa Carvalho Júnior |
| Modalidade de apoio: | Bolsas no Exterior - Estágio de Pesquisa - Doutorado |