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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Mood disorders in the elderly: prevalence, functional impact, and management challenges

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Autor(es):
Lane Valiengo, Leandro da Costa ; Stella, Florindo ; Forlenza, Orestes Vicente
Número total de Autores: 3
Tipo de documento: Artigo de Revisão
Fonte: NEUROPSYCHIATRIC DISEASE AND TREATMENT; v. 12, p. 2105-2114, 2016.
Citações Web of Science: 20
Resumo

Despite the lower prevalence of severe mood disorders in the elderly as compared to younger adults, late-life depression and bipolar disorder (BD) are more strongly associated with negative outcomes related to the presence of medical comorbidities, cognitive deficits, and increased suicide risk and overall mortality. The mechanisms that contribute to these associations are probably multifactorial, involving pathological factors related directly and indirectly to the disease itself, ranging from biological to psychosocial factors. Most of the accumulated knowledge on the nature of these associations derives from naturalistic and observational studies, and controlled data are still scarce. Nonetheless, there has clearly been a recent growth of the scientific interest on late-life BD and geriatric depression. In the present study, we review the most relevant studies on prevalence, clinical presentation, and cognitive/functional impact of mood disorders in elderly. Several clinical-epidemiological studies were dedicated to the study of the prevalence of mood disorders in old age in distinct settings; however, fewer studies investigated the underlying neurobiological findings and treatment specificities in late-life depression and BD. In the present study, we further discuss the implications of these findings on the management of mood disorders in older adults. (AU)

Processo FAPESP: 11/19892-3 - Efeitos do lítio sobre a expressão e atividade das enzimas Fosfolipase A2 e glicogênio sintase quinase 3B e sua relação com o estado de fosforilação da proteína Tau
Beneficiário:Vanessa de Jesus Rodrigues de Paula
Linha de fomento: Bolsas no Brasil - Doutorado